echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Wang Chengshu's research group reveals the regulatory mechanism and function of insect fungal synthesis of 2-pyridone

    Wang Chengshu's research group reveals the regulatory mechanism and function of insect fungal synthesis of 2-pyridone

    • Last Update: 2022-01-10
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    On December 14, 2021, the international academic journal mBio published online a research paper entitled "Inductive production of the iron-chelating 2-pyridones benefits the producing fungus to compete for diverse niches" by Wang Chengshu's research group
    .


    This work reported that when the entomopathogenic fungus Beauveria bassiana competes with other fungi, it induces the production of 2-pyridone compounds with iron ion chelating activity, which helps Beauveria bassiana to antagonize other fungi and deal with iron deficiency.


    Beauveria bassiana is widely used in the biological control of agricultural and forestry pests.
    The genome of this bacteria contains secondary metabolic gene clusters that synthesize different active ingredients.
    However, under normal culture conditions, they are mostly silent.
    Different gene clusters are responsible for the structure and structure of metabolites.
    The activity, synthesis mechanism, and biological function are unclear
    .


    The previous research of the research group showed that when Beauveria bassiana and Metarhizium Roberts mixed infect insects, the former acted as a "weak person", that is, it could not compete with Metarhizium anisopliae to infect the same individual insect under the same spore concentration; but in vitro Under culture conditions, Beauveria bassiana can inhibit and repel the growth of Metarhizium anisopliae, thus exhibiting adaptive environmental competition ( J.


    The research in this paper found that the mixed fermentation of Beauveria bassiana and Metarhizium anisopliae can induce the production of a new class of compounds
    .


    Structural identification showed that this class of compounds are 2-pyridone alkaloids, which are synthesized by the conservative polyketide synthase and non-ribosomal polypeptide synthetase (PKS-NRPS) TenS gene cluster, which only exists in Beauveria bassiana , And it is silent in pure culture


    This work enriched the biosynthesis and regulation mechanism of 2-pyridone alkaloids, and proved that 15-HT, which has iron chelating function, has important ecological functions for Beauveria bassiana
    .

    Dr.
    Chen Bo and Sun Yanlei, graduate students of the Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, are the co-first authors, and researcher Wang Chengshu is the corresponding author
    .


    This research was funded by the National Foundation of China Innovation Group and the Frontier Science Key Research Program of the Chinese Academy of Sciences


      Link to the paper: https://journals.


    Beauveria bassiana synthesizes 2-pyridone and its series of precursors and derivatives (red markers are newly identified compounds)

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.