Wang Yun's research group reveals a new mechanism of pain epigenetic regulation and develops specific small molecule compounds with analgesic effect

? ? ? On February 4, 2022, the research group of Professor Wang Yun from Peking University School of Basic Medicine published a research paper entitled "Cdyl deficiency brakes neuronal excitability and nociception through promoting Kcnb1 transcription in peripheral sensory neurons" in Advanced Science

Involvement of CDYL in the regulation of pain perception in peripheral sensory neurons

? ? ? In physiological state, CDYL in DRG is involved in maintaining neuronal excitability and nociception

? ? ? Chronic pain is a major health problem in today's world.

? ? ? CDYL is an important epigenetic regulator

? ? ? In this study, the research group found that CDYL is widely distributed in large, medium and small diameter neurons in dorsal root ganglia (DRG), and peripheral nerve injury can induce its up-regulation

? ? ? In conclusion, this study revealed for the first time the regulatory mechanism of CDYL in peripheral sensory neurons involved in pain perception and the occurrence and development of chronic pain

? ? ? Professor Wang Yun from Peking University School of Basic Medicine and Professor Lindsey I.

(Peking University School of Basic Medicine)

[Original link]: http://doi.