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There are many micro-nano-scale things in nature that can swim freely, such as molecular motors, biological motors, bacteria, sperm, etc.
Many micro-nano drug-carrying robots rely on self-propelled motion and cross the barriers of multiple biological barriers to deliver drugs to the bottom of the eyeball or deep in the brain tissue, causing thorny medical problems such as glaucoma, epilepsy, glioma, stroke and hemiplegia has been solved.
The reporter learned from Harbin Institute of Technology (hereinafter referred to as Harbin Institute of Technology) on April 19 that the research paper completed by the group of professors He Qiang and Wu Zhiguang of the micro and nanotechnology research center of the school "Dual response biological hybrid neutrophil robot for active targeting Delivery, recently published online in the international "Science Robot" magazine.
Building active drug transport channels has become a hot spot in the industry
According to reports, conventional drug delivery, such as injections, medications, and infusions, all rely on the diffusion of drug molecules or carriers in the blood, resulting in low delivery efficiency.
In 1966, a foreign film called "Fantasy Journey" described a medical scientist suffering from a serious illness.
Looking back in history, the first to propose the idea of a micro-nano machine was Richard Feynman, a Nobel Prize winner and theoretical physicist.
What is gratifying is that since 2004, a variety of swimming micro-nano robots driven by chemical and external physical fields (such as photoelectromagnetic heat, etc.
The atomically assembled "swimmer" can fool the immune system
Professor Wu Zhiguang, director of the Micronano Actuator and Microsystem Branch of the Chinese Society of Micro, Micro and Nano Technology and a doctoral tutor of Harbin Institute of Technology, said that the early swimming micro and nano robots were basically composed of micro-electromechanical systems and other components, and their materials were mainly metals and metal oxides.
In addition, “The first thing to solve for the development of micro-nano size robots is the driving problem.
Scientists have discovered that there are many micro-nano-scale things in nature that can swim freely, such as molecular motors, biological motors, bacteria, sperm, etc.
Clinical translation application depends on two important links
"However, if these micro and nano robots are to be transformed into clinical applications in the future, there are two important links that cannot be avoided.
The second is the imaging and control of swimming micro-nano robots.
Among the important results that have been achieved, He Qiang’s team has developed for the first time a robot that can effectively and stably carry anti-cancer drugs such as paclitaxel.
Looking to the future, nanotechnology is no longer just the cool technology that superheroes in Hollywood blockbusters have, it will become a part of human life.
"The prospect is bright, and the future can be expected!" He Qiang said frankly that the road of future exploration is still very difficult and long.