Was Science issued a new issue of Neutralizing Antibodies on June 15th? 5 full articles.

The outbreak of the new coronavirus continues to occur, and there are no specific drugs available for treatment of the diseaseBut through the tireless efforts of global scientists, there has been a lot of good news in the near future, such as dexamethasone can reduce the mortality rate ofCOVID-19severe patients, some vaccine clinical trials are ideal, even to achieve a 100% impotence rateIn particular, the recent research on neutralizing antibodies in the new coronavirus has been outstandingOn June 15th Science published five research papers on neutralizing antibodies in the new coronavirus, which became a "special issue"human-sourced antibodies and antibody "cocktail therapy" has a blocking effect on viral transmission, and is of great significance for the design of therapeutic antibody drugs and protective vaccinesYiju Shenzhou has successfully constructed a variety of new coronavirus neutralizing antibodies, after ELISA and false virus experiments proved that these antibodies have good neutralactivity, can specifically identify the antigen protein of the new coronavirusone of the five articles studied the mutants of the new coronavirus S proteinIt was found that there were 4 neutralizing antibodies that effectively inhibited the sprotein of the new coronavirus S, and that were still effective for the mutants of s proteinAnd through the antibody cocktail combination, the occurrence ofimmunityescapesuccessfully screened more than 1,800 antibodies in a Scripps Research Institute study, including the receptor binding domain RBD region and the non-RBD region of the targeted S proteinUsing mouse models to detect the protective effect of neutralized antibodies, two kinds of antibodies with theof the of the new coronavirus infection were found to have a clear protective effect researchers at the University of Amsterdam in the Netherlands immunized against the new coronavirus S protein in a stable pre-fusion conformation, obtaining 403 monoclonal antibodies, indicating that these antibodies have a strong immune response to the S protein Cell experiments found that 19 kinds of antibodies can be combined against different antigen sites of S protein, of which 2 antibody IC50 value slower than 10 ng/mL, indicating a high neutralactivity New coronavirus live virus detection, IC50 as low as 7 ng/mL article also reported an all-human antibody that targets the new coronavirus S protein and enters clinical trials In the study, the structure of the RBD complex was analyzed by the antibodies that combined with the strong neutrality of the RBD region, and found that the two antibodies had different binding sites another study aimed at developing neutralizing antibodies to a broad-spectrum anti-coronavirus The researchers screened 200 antibodies targeting multiple conservative sites on the S protein from the memory B cell pool of patients with recovery period SARS, while combining the new coronavirus Antibodies are intended to provide ideas for the design of coronavirus vaccines by blocking receptor attachment and inducing S1 protein shedding, effectively neutralizing viruses such as SARS-COV and SARS-COV-2 , the progress of research on neutralizing antibodies in the new coronavirus has raised hopes for COVID-19 treatment and provided new ideas for therapeutic antibody drug development and vaccine development At present, there are a variety of domestic and foreign neutralizing antibodies completed model animal safety testing, has begun clinical trials, I believe that soon will come a good letter Source: yiju Shenzhou