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    Home > Active Ingredient News > Antitumor Therapy > Waters launches SELECT SERIES MRT multi-reflection time-of-flight mass spectrometry platform, setting a new benchmark for high-resolution mass spectrometry performance

    Waters launches SELECT SERIES MRT multi-reflection time-of-flight mass spectrometry platform, setting a new benchmark for high-resolution mass spectrometry performance

    • Last Update: 2021-12-03
    • Source: Internet
    • Author: User
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    Waters Corporation (NYSE: WAT) grandly launched the Waters SELECT SERIES MRT high-resolution mass spectrometer , which combines multi-reflection time-of-flight (MRT) mass spectrometry technology with improved DESI and a new MALDI imaging ion source.
    The advantages of high-speed, high-resolution, and high-quality precision are combined to help scientists
    accurately identify and locate individual molecules in samples, so as to in-depth study of molecular structure and functions
    .

    Waters SELECT SERIES MRT high-resolution mass spectrometer is accurate

    For example, when scientists are studying how candidate tumor drugs interact with expected targets (such as specific brain tumor receptors), they can collect data at speeds of up to 10 Hz without affecting quality accuracy or resolution.
    , To get results faster than ever

    .

    Dr.
    Udit Batra, President and CEO of Waters Corporation, said: "Waters SELECT SERIES MRT has opened the door to more in-depth exploration of molecules and their mechanisms of action in many scientific research fields

    .
    This instrument can generate very clear images.
    It helps scientists in research fields such as targeted therapy to unearth key information related to molecules, making it possible to deeply explore the mysteries of biomedicine

    .
    "

    The SELECT SERIES MRT platform is the foundation stone of Waters' new generation of high-resolution mass spectrometers
    .
    It is the first to achieve a resolution of up to 200,000 FWHM, quality accuracy to the ppb level, and performance independent of scanning speed among similar commercial products on the market

    .
    The SELECT SERIES MRT platform allows scientists to obtain high-quality mass spectrometry data and information faster, and its outstanding performance leads other commercial mass spectrometers on the
    marketi
    .
    The innovative multi-reflection time-of-flight technology extends the ion flight path to nearly 50 meters, helping scientists to collect clearer structural information, even including fine isotope structures

    .

    i

    Both DESI XS and MALDI imaging capabilities MRT integration platform

    Both DESI XS and MALDI imaging capabilities MRT integration platform

    The newly launched SELECT SERIES MRT platform from Waters unleashes the MS imaging potential of DESI and MALDI ionization technologies
    .
    DESI is a "soft" ionization technology that can be sampled under atmospheric pressure.
    There is no need to prepare samples, and a wealth of imaging information can be collected by only running a measurement, revealing the presence of small molecule drugs, lipids and natural metabolites in tissue sections.
    Biochemical distribution within or on the surface of other samples

    .
    DESI is currently widely used.
    Scientists use this technology to study
    breast and ovarian cancer , conduct drug metabolism and pharmacokinetics (DMPK) studies, study how various key metabolites of natural products used in traditional medicine work, and In-depth exploration of the biotransformation of bacterial communities after genetic modification
    .

    Breast Cancer Ovarian Cancer

    The advanced DESI XS ion source is equipped with a brand-new high-performance nebulizer and thermal transmission line.
    The scope of application, imaging clarity and sensitivity are better than before, while maintaining a high scanning speed, allowing scientists to obtain imaging information more easily by collecting mass spectrometry data

    .

    For the convenience of scientists who need to carry out MALDI imaging experiments, SELECT SERIES MRT is equipped with a newly designed MALDI ion source of Waters
    .
    MALDI is an ideal supplementary technology for biomolecular imaging applications such as peptide imaging.
    It can slice tissues with a spatial resolution as low as 10 microns

    .

    Thanks to the combination of these two imaging ion sources, researchers can obtain fine spatial information and morphological details from biological samples, and even visualize cerebral blood vessels
    .
    SELECT SERIES MRT is expected to start supplying customers in the fourth quarter of this year

    .

    Blood vessel

    Other references

    Other references
  • Learn more about Waters SELECT SERIES MRT
  • Waters SELECT SERIES MRT
  • Watch the SELECT SERIES MRT product video
  • SELECT SERIES MRT product video
  • Learn more about the Waters DESI XS ion source
  • Waters DESI XS
  • Read Waters blog post: New SELECT SERIES MRT Performance REDEFINES the Next Generation of High-Resolution Mass Spectrometry (new SELECT SERIES MRT establish a new performance benchmark for high-resolution mass spectrometry)
  • New SELECT SERIES MRT Redefines Performance of Next Generation High-Resolution Mass Spectrometry New SELECT SERIES MRT Redefines Performance of Next Generation High-Resolution Mass Spectrometry

    About Waters Corporation ( )

    About Waters Corporation ( )

    Waters Corporation (NYSE: WAT) is a world-leading professional measuring instrument company.
    As a pioneer of innovative technologies in chromatography, mass spectrometry, and thermal analysis, Waters has served life sciences, materials sciences, and food sciences.
    More than 60 years of history

    .
    Waters directly operates in 35 countries and regions, has 14 production bases, has more than 7,400 employees, and sells its products to more than 100 countries and regions

    .

    About Waters China

    About Waters China

    Since entering China in the 1980s, Waters has grown in scale and strength, with operation centers in the mainland, Hong Kong and Taiwan, with more than 600 local employees, and experimental centers in Shanghai, Beijing, Guangzhou, and Chengdu.
    And training center

    .

    Since the establishment of Waters Technology (Shanghai) Co.
    , Ltd.
    in 2003, China today has become the second largest market in Waters' global revenue after the United States

    .
    As a partner of analytical scientists, Waters has always insisted on improving local technical capabilities, supporting the cultivation of local technical talents, and promoting the establishment and improvement of relevant industry standards and regulations such as pharmaceuticals, food safety, health sciences, and environmental protection

    .

    With outstanding talents and global presence, Waters has created significant value for its business partners and is committed to meeting the needs of Chinese consumers for a better life
    .


    Waters SELECT SERIES MRT quality resolution> 200k FWHM @ m/z 785, and is not affected by the scan time; superior resolution can be achieved at any scan rate

     

    Fig.
    Waters SELECT SERIES MRT platform (equipped with DESI XS ion source)



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