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The Wuhan Institute of Virusresearch of the Chinese Academy of Sciences has made new progress in the study of the nucleogene nucleogeneation of human cytomegalovirus, and the study has found that the host cell protein WDR5 plays an important role in the nuclear process of human cytomegavirus nucleogeneation by assisting in the formation of nuclear complex.
research results recently published online in the international authoritative journal Virology.
this study for the first time reveals the role and mechanism of WDR5 in the human cytomegalovirus replication cycle, deepens the understanding of the replication process of this important pathogen virus, and also provides new ideas for the development of antiviral drugs.
human cytomegalovirus is a very high infection rate in the population of the virus.
congenital human cytomegalocyte virus infection is the most common infectious cause of birth defects in newborns, which can lead to abnormal fetal neurodevelopment, and the activation of latent infection often causes fatal infection senile infection in transplant recipients.
Luo Minhua researcher, WDR5 belongs to the Family of WD40 Repeat protein, which plays an important role in the regulation of a variety of cell important physiological processes.
the protein's role in human cytomegalovirus infection is not known.
study found that human cytomegalovirus infection into fibroblasts by inhibiting the host protein WDR5 ubiquitin degradation pathway, and so on, and thus increase their protein levels.
in-depth study found that overexpression of WDR5 only slightly increased the production of human cytomegalovirus particles.
knocking down WDR5 had no significant effect on the virus's entry into host cell, viral genome replication, viral gene expression, and the formation of nuclear shell, but it significantly inhibited the production of infectious virus particles.
experts on the late steps of human cytomegalovirus replication in-depth study found that knocking down WDR5 makes the formation of human cytomegavirus nuclear complex damaged, and reconstructing the expression level of WDR5 can restore the production of human cytomegavirus virus particles.
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