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On February 7, The Emerging Microbes and Infections of Nature magazine published a research paper by Chen Quanxuan, a researcher at the Influenza Research and Early Warning Center of the Chinese Academy of Sciences and the Wuhan Virus Research Institute of the Chinese Academy of Sciences.
the study revealed that wetlands and lakes in central China may play a key role in the spread of the H5N8 virus, illustrate the variation of amino acids as the virus spreadacross across species, and highlight the need for continuous monitoring of the H5N8 virus in the wild bird and live poultry markets.
Since 2016, the highly pathogenic avian influenza H5N8 virus has been in the european route through migratory bird migration in Central Asia, resulting in a large number of deaths among poultry and wild birds.
in the study, researchers isolated and identified three H5N8 viruses from Hongyu and Black Swan in Hubei Province in the winter of 2016/2017.
genome-wide sequencing and evolutionary analysis showed that the three viruses were classified as a group of H5N8 viruses from Qinghai Lake and Europe.
a new recombinant virus isolated from Hongyu is different from the black swan because its PA and NP genes are different from the Qinghai Lake virus.
molecular dating dates show that the ancestral strains of these H5N8 viruses appeared around July 2015.
by sequence comparison, the researchers found that eight amino acids were replaced on HA and NA, in the process of adaptation from poultry to wild birds.
the three viruses are isolated from wild birds on migratory bird migration routes in East Asia-Oceania, however their genomes are similar to the H5N8 virus, which is prevalent on migratory bird migration routes in Central Asia.
from the data, the researchers concluded that wetlands and lakes in central China may play a key role in spreading the H5N8 virus between migratory routes in East and Oceania and Central Asia.
the research support edited by the Key Research and Development Project of the Ministry of Science and Technology of China, the National Natural Science Foundation of China, the Wuhan National Biosecurity Four-Level Laboratory Open Research Fund and the Shenzhen Science and Technology Research and Development Project.
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