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    Home > Biochemistry News > Biotechnology News > What about superbugs? Can PPMO solve it?

    What about superbugs? Can PPMO solve it?

    • Last Update: 2020-09-13
    • Source: Internet
    • Author: User
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    U.S. scientists have developed a new weapon that promises to fight drug-resistant superbugs, foreign media reported.
    experts have used a new molecule to suppress the bacteria's resistance to antibiotics, so that drug-resistant bacteria can also be killed by existing antibiotics, as soon as 3 years is expected to be clinically effective in humans.
    reported that superbugs have been listed as a major threat by the United Nations.
    a 2014 BRITISH government study warned that superbugs could kill as many as 300 million people by 2050.
    , a professor of microbiology at Oregon State University who led the new study, noted that many common antibiotics are no longer available for treatment because of the spread of drug-resistant bacteria.
    Although humans are constantly trying to develop new drugs or retrofit existing antibiotics, germs can mutate to become resistant, and scientists are trying to study ways to combat superbugs by following the mechanisms by which bacteria develop resistance.
    team studied New Delhi Metal-beta-endamidease 1 (NDM-1), an enzyme that gives bacteria resistance.
    NDM-1 breaks down a variety of antibiotics, including carbapenems, which are considered the last line of defense against drug-resistant diseases.
    team produced a substance specifically inhibited by NDM-1, phosphate diamide (PPMO), and tested three bacteria in the lab that produce NDM-1 and one of its most widely effective carbapenem antibiotics, meropenem, and found that under PPMO, the bacteria in question lost resistance and were able to be killed by antibiotics.
    experts then used PPMO and Meropenan to infect mice infected with the drug-resistant E. coli, which contained NDM-1, resulting in a 92% increase in survival and a significant reduction in the number of drug-resistant E. coli in mice.
    that previous studies have used naturally occurring PPMO to fight drug-resistant bacteria, but only for specific bacterial strains.
    because different types of drug-resistant bacteria have the same gene used to produce NDM-1, finding a substance that effectively inhibits the gene can be applied to most drug-resistant bacteria.
    believes the newly developed PPMO could be used in the same way as existing antibiotics, making ineffective drugs useful again.
    the study was published in the Journal of Antibacterial Chemotherapy.
    .
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