What are cysteine protease inhibitors?

Cysteine protease is an enzyme that can decompose polypeptides (amino acid chains that make up proteins) The cysteine protease inhibitor is a kind of substance for this enzyme The mechanism of pathogen activity has been confirmed to involve the use of cysteine protease There is evidence that caspase plays a role in cancer proliferation, osteoporosis, Alzheimer's disease, arthritis and microbial infection Cysteine protease inhibitors can resist these diseases by preventing the enzyme Papain, cathepsin, caspase and calpain are the main cysteine proteases found in plants and animals Cysteine protease inhibitor is a kind of protein which can help to counteract the poor activity of cysteine protease Some inhibitors can prevent protease from entering, or force them to self destruct Cells themselves have strategies to protect themselves and resist the activity of malignant protease Apoptosis inhibitors are a family of proteins that can interfere with programmed cell death As inhibitors of caspase, these proteins bind to caspase and inhibit its function Many viruses depend on the activity of caspase to reproduce Cystatin is composed of different groups of caspases, which can protect tissues from the damage of pathogenic caspases Scientists isolated the first cysteine protease inhibitor from eggs It has been proved that caspase inhibitors can inhibit caspase, papain and cathepsin Serine protease inhibitor is another protein with the function of cysteine protease inhibitor These proteins have unique suicide inhibition properties, similar to the mechanism of papain and cathepsin inhibition Serine proteases inhibit protein recognition, bind to cysteine proteases, and permanently alter their structure This transformation can prevent the normal function of protease At present, scientists have identified three serine protease inhibitors in human body It has been found that caspase inhibitors can significantly reduce parasite proliferation Parasites produce cysteine proteases, which play an important role in invading and destroying tissues The natural resistance of parasites forces researchers to find different ways to deal with them, while caspase inhibitors offer another alternative treatment for resistant parasite infections The scientists also studied the effect of caspase inhibitors on Alzheimer's disease The disease involves an abnormal accumulation of beta amyloid in the brain In animal experiments, caspase inhibitors reduced the level of β - amyloid in the brain to 70% This effect can improve the memory ability of patients with Alzheimer's disease.