What are mature inhibitors?

Maturation is one of the last steps in the life cycle of HIV and involves the viral protein processing required for HIV to be infectious HIV mature inhibitors are potential new molecules, and their ability to prevent the processing of these proteins is still under study Researchers expect to prevent HIV infection by using mature inhibitors In a simplified version of the HIV life cycle, HIV first binds and fuses the cell membrane of the host cell to inject virus content into the cell Then, the HIV genome is reverse transcribed from RNA to DNA, and the viral DNA is integrated into the host cell genome At this point, the virus may be dormant for a period of time, or immediately start to produce new virus products such as RNA or protein for later assembly and release of infectious virus particles An important step in HIV maturation is the treatment of Gag proteins Gag is actually a kind of protein, which means that it was originally produced as a long thread of different proteins, and then cut the functional part successfully Gag proteins must be cut into small pieces by HIV protease to produce structural proteins (important for assembling infectious HIV particles) The function of mature inhibitors is to inhibit the process of gag treatment by binding Gag proteins and preventing HIV protease cleavage, and to prevent virus particles from infecting other host cells It is important to develop new HIV inhibitors, because AIDS treatment often involves different types of drugs to fight as many stages of the HIV life cycle as possible In addition, HIV can mutate during drug exposure, leading to resistance, and producing HIV strains that are resistant to the entire class of drugs Therefore, the introduction of mature inhibitors and other new drugs can provide an effective treatment for patients who have exhausted all the drugs Bevirimat is a mature inhibitor isolated from Chinese herbal medicine, which has shown promising results in clinical trials.