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    Home > Active Ingredient News > Drugs Articles > What are monoamine oxidase inhibitors?

    What are monoamine oxidase inhibitors?

    • Last Update: 2020-04-03
    • Source: Internet
    • Author: User
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    Monoamine oxidase inhibitors (MAOIs) are a kind of antidepressants They are often used to treat atypical depression and quit smoking Because of strict dietary restrictions, this kind of antidepressants are not widely used as other types of drugs They have a lethal risk of interacting with other drugs, health products, and food or alcoholic beverages Depression is generally believed to be caused by imbalances in brain chemicals (neurotransmitters) Examples of mood related neurotransmitters are serotonin and noradrenaline If these compounds are not enough in the body, it can lead to depression These special compounds are monoamines, meaning there is an NH2 group Monoamines are degraded by enzymes called monoamine oxidase Monoamine oxidase inhibitors can inhibit monoamine oxidase and prevent monoamine decomposition This can make the neurotransmitters involved in emotion accumulate, so as to alleviate depression The United States began to use monoamine oxidase inhibitors in the 1950s, but later withdrew from the market due to the fatal interaction with other substances Some foods contain monoamines, such as tryptophan or its decomposition products, so it is important to avoid foods and specific drugs that contain these substances when taking monoamine oxidase inhibitors Patients should avoid most alcoholic beverages, aged cheese, pickled herring, broad beans and animal liver and other food Users should also eat as little chocolate as possible In short, there are many dietary taboos when taking this kind of medicine For example, tyramine interacts with monoamine oxidase inhibitors, leading to high blood pressure and stroke Attention should also be paid to health care products such as St John's wort when taking medicine, because the interaction is very dangerous In addition, any stimulant should also be avoided, such as products containing pseudoephedrine Dolantin and other painkillers are common components of cough syrup and asthma inhalers, and there is a risk when they are used together with monoamine oxidase inhibitors In addition, selective serotonin reuptake inhibitors should not be taken at the same time In order to ensure safety, it is best to have a two-week interval between the conversion of the two drugs Because of these contraindications, monoamine oxidase inhibitors are often the last choice to cure depression However, it is an ideal choice for some patients, such as atypical depression and social phobia Patients with atypical depression often have a combination of depression and anxiety People with panic and agoraphobia can also benefit from these drugs Unless it is serious depression, this kind of antidepressant will not be used Monoamine oxidase inhibitors also have some benefits, such as they do not cause suicidal thoughts in non suicidal people It's also a side effect of some other antidepressants However, people with potential suicidal tendencies are not suitable to use the drug because of the risk of poisoning in large doses In addition, the drug should not be given to pregnant women or children younger than 16 years old Common monoamine oxidase inhibitors include phenylethylhydrazine (nardil ®), parnate ®, and marplan ® There is also a skin patch called emsam ®, which has less side effects at low doses, but should also be used with caution At present, a new class of monoamine oxidase inhibitors called Rima has been developed In addition to reversibility, the interaction with tyramine is not very strong, so the dietary impact is not a big problem But people still can't eat too many foods containing tyramine These drugs can be used to treat major depression.
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