What are the side effects of NSAIDs?

Non steroidal anti-inflammatory drugs (NSAIDs) are also called non steroidal anti-inflammatory drugs, including aspirin and ibuprofen Paracetamol is sometimes considered as a non steroidal anti-inflammatory drug, but its anti-inflammatory effect is less Nonsteroidal anti-inflammatory drugs are mainly used to treat pain, fever and inflammation They are generally considered to be very safe drugs for most patients They are most commonly used for headaches, muscle soreness or other injuries, arthritis, menstrual pain, cramps and mild fever More severe pain or inflammation may require steroids or opiates One of the benefits of NSAIDs, compared with steroids and opiates, is that they have relatively small side effects and are not addictive Although steroidal anti-inflammatory drugs have better efficacy, they have a wide range of side effects Opium drugs can easily lead to drowsiness, dizziness, embarrassment and sometimes addiction Although different non steroidal anti-inflammatory drugs contain different chemical components, they have similar effects on pain and swelling, mainly on cyclooxygenase in the body These enzymes are responsible for swelling response to injury Therefore, inhibition of cyclooxygenase can reduce swelling Cyclooxygenase-1 regulates the secretion of mucus in the lining of digestive tract and prevents the stomach from being damaged by its own digestive fluid As these mucus secretion will also be inhibited by non steroidal anti-inflammatory drugs, it will bring side effects such as heartburn and nausea to some people Nonsteroidal anti-inflammatory drugs are also acidic in themselves, which will further cause gastrointestinal discomfort Celebrex and other new non steroidal anti-inflammatory drugs only selectively inhibit cyclooxygenase-2 enzyme, so the side effects of gastrointestinal discomfort are less But because it is a new drug, it is not covered by medical insurance, and the price of such drugs is high.