What do you know about the active ingredients of party ginseng? A list of pharmacological effects and clinical applications

Party ginseng for orange terrier plant party ginseng, vegetarian party ginseng and Sichuan party ginseng dry root, is commonly used to supplement the chinese medicine, with spleen beneficial lung, blood-raising work.
party participation in phytochemical composition is complex.
So far, scholars at home and abroad have isolated and identified more than 230 kinds of compounds from party-participating plants, including alkaloids, steroids, terpenes, flavonoids, ligands, steroids, sugars and other components.
, alkaloids, polyphenyls, limes, flavonoids and polysaccharides are considered to be the main active ingredients.
roles of party ginseng pharmacology are rich and diverse, mainly in the nervous system, endocrine system, immune system and so on.
a large number of studies have found that party participation in the protection of nerves, anti-tumor, antioxidant, anti-inflammatory, anti-stress, liver preservation and other effects.
1, the protection of the nervous system party ginseng extract has the protection of nerve cells, improve learning and memory ability and reduce Alzheimer's disease (AD) symptoms and other neurological protective effects.
party ginseng water pickup and monobiome component Lancemaside A can increase the activity of protein phosphatase 2 (PP2A), reduce the phosphorylation level of Tau protein, repair damaged neurons, inhibit AChE activity.
the total alkaloid can enhance the neurotic growth of PC12 cells and increase the phosphate of the active protein kinase of fissures.
the survival rate of brain astroid glial cells after istemia and refill damage in rats.
other studies have shown that ginseng polysaccharides mainly block excessive phosphateization of AD-like tau proteins by activating PP2A.
2, regulating blood sugar and blood lipid party ginseng extract has the effect of regulating blood sugar and blood lipids.
party ginseng can lower blood sugar, inhibit the activity of aldehyde glycase, delay the progression of diabetes.
party general saponin can reduce the total serum cholesterol, triglyceride, LDL cholesterol content in rats with hyperlipidemia, improve the cholesterol content of NO and HDL, and have the effect of regulating blood lipids.
ginseng polysaccharid CLPS reduces insulin resistance induced by a high-fat/high-sugar diet through antioxidant stress.
ginseng-neutral polysaccharose significantly improved insulin secretion in INS-1 cells and reduced blood sugar levels in mice with type 2 diabetes.
3, the role of the immune system party ginseng has the role of regulating the body's immune balance.
party methanol extract can regulate macrophage-mediated immune response and promote anti-inflammatory activity.
oral solution can improve the immune function of immunosuppressive mice caused by cyclophosphamide.
addition, after the party general saponin is made into nano-milk, it has enhanced the regulation function of cell immunity, body fluid immunity and non-specific immunity.
as a natural immunomodulant, can maintain the balance of T cells in mice.
ginseng polysaccharin reduces sepsis in mice with blind intestinal colonation and puncture by regulating T-cell circulation.
ginseng polysaccharies can promote the phagocytosis of albedo macrophages with chronic obstructive pulmonary disease injury and improve inflammatory response.
polysaccharide selenium can improve the phagocytosis index of peritonal macrophages and induce TNF-α and IL-6 secretion.
polysaccharines can activate macrophages and inhibit the proliferation and migration of cancer cells.
two types of gel-type polysaccharid RCAP-1 and RCAP-2 also have significant immunomodulation effects.
4, the role of the digestive system party ginseng extract has the treatment of stomach ulcers, promote intestinal promotion, improve the body's digestive capacity and other pharmacological effects.
japanese large-eared white rabbit infusion party ginseng frying agent, gastric sinuses and duoon mucosa tissue growth inhibition concentration increased significantly, indicating that party ginseng can treat peptic ulcers.
party water picker can promote detopies in constipated mice.
party ginseng ultra-micro-powder can protect the stomach mucous membranes of gastric ulcers rats.
party ginseng flavonoid extraction site can promote cell migration in the small intestine endothride cells, reverse cell migration inhibition caused by DFMO or 4-AP, and increase the amount of arginine in cells, which may be associated with polyamine signaling pathlines.
party ginseng can improve the content of prostatin (PG), counter the acid action of gastin (Gas), stimulate the gastric mucosa synthesis release epithelide growth factor, ethanol caused by gastric mucosa damage has a certain protective effect.
party ginseng polysaccharides can increase the thickness of the gastric mucosa and stomach wall, promote the growth of intestinal fluff, promote intestinal peristalsis, improve digestion ability, regulate the intestinal bacteria of colitis mice.
can improve gastrointestinal function by changing the composition and metabolism of the gut microbiome, which is a potential probiotic and a potential component in the treatment of acute stomach ulcers.
5, the effect on blood circulation party ginseng extract has the effect of treating heart failure, regulating blood cell growth and development, enhancing hematogenesy function, inhibiting plateplate aggregation and so on.
party ginseng can reduce the damage of insulin-like growth factor II to myocardial cells and reduce apoptosis of myocardial cells.
party ginseng solution can reduce the end-stage pressure of left chamber throosia, inhibit MDA, LDH, CK elevation, enhance SOD, GSH-Px, Na-K-ATP and Ca2-ATP vitality, and have a protective effect on myocardial isoemia/refill damage.
same time, party ginseng extract can improve the maximum rate of pressure rise/decrease in the left heart, improve the symptoms of chronic heart failure rats, delay the occurrence and development of chronic heart failure.
party ginseng particle agent can shorten the time of calcium transient decline and treat heart failure by increasing the blood test score, short shaft shrinkage rate of left chamber, and calcium transient peak.
6, antibacterial, anti-viral modern research found that party ginseng has antibacterial, anti-viral effects.
in vitro antibacterial experiments found that the party ginseng ethanol extract has significant inhibitory effect on common bacteria such as Staphylococcus aureus, Staphylococcus aureus, anthrax bud Cytobacteria, E. coli, typhoid salmonella, etc.
party polysaccharin can reduce the expression level of IFN-β and inhibit the toxicity of the duck hepatitis A virus.
7, anti-tumor party ginseng can promote HL-60 apoptosis.
party ginseng can inhibit the proliferation of HepG2 cells and SMMC-7721 cells in human liver cancer.
soluble polysaccharides CPP1a and CPP1c can activate caspase-3 by raising the ratio of Bax/Bcl-2 to induce HepG2 apoptosis.
addition, it also has some cytotoxicity to cervical cancer Hela cells and stomach cancer MKN45 cells.
party ginseng polysaccharine has obvious cytotoxicity to A549 cells of human lung adenocarcinoma.
ginseng acid polysaccharides are a potential candidate compound to prevent tumor metastasis, which inhibits the invasion, migration and adhesion of HO-8910 cells of human ovarian cortification tumors.
clinical application of party ginseng is more common, can be used to treat cardiovascular diseases, gynecological diseases and relieve stress response caused by physical discomfort, but also as an auxiliary drug to improve the efficacy of Western medicine, reduce adverse reactions.
Party ginseng, because of its complementary effect, has become a commonly used drug for clinical treatment of anemia, and has therapeutic effects on gas-blood type two-void type, spleen-kidney impotence type, liver and kidney yin type and renal hemorrhoid anemia type.
observation compares the single use of raw pulse injection and party ginseng jaundice square (party ginseng, the place of life each 20g, wheat winter, five miso, heron, yellow cypress, Sichuan cow knee, kernels, when return, Sichuan, licorice each 10g, the system appendix 5g) joint vein injection to IDH The therapeutic effect of (low and medium blood pressure in dialysis) was measured by clinical symptoms, systolic pressure, diastolic pressure, hemoglobin (Hb), plasma albumin (ALB), C reaction protein (CRP) level and adverse reactions after one week of taking the drug.
party members for chronic atrophy gastritis, Helicobacter pyrethrobacteria infectious gastric disease, functional indigestion spleen liver depression and other digestive diseases are accurate.
addition, party ginseng can also be used to treat acute altitude reactions, postpartum milk self-production, schizophrenia, diabetes combined depression, heart failure, kidney failure and functional uterine hemorrhage.
References: Wang Han, Lin Hongqiang, Tan Jing, et al. Progress in the Pharmacological Role and Clinical Application of Party Participation. World's Latest Medical Information Digest, 2019, 19 (07): 27-28-30. Xie Wei, Cheng Xuemei, Hu Fangdi, Wang Changhong. Progress in research on chemical composition, pharmacological effects and quality control of party members. Shanghai Journal of Traditional Chinese Medicine, 2020, 54 (08): 94-104. Introduction to the author: Small silt, food science and technology workers, graduated from the School of Food Science and Engineering of South China University of Technology, Master of Food Science, is now working in a large domestic pharmaceutical research and development company, engaged in the development and research of nutritious food.