What does it mean that the new crown vaccine is 79.34% effective? Can I fight between the ages of 3 and 17?

China's first new crown vaccine has begun to vaccinate key populations in many places.
the current capacity of the new crown vaccine? What does the 79.34 per cent effectiveness mean? How long is the protection period for the new crown vaccine? Can 3- to 17-year-olds get a new crown vaccine? Zhang Yuntao, vice president of China Biology at China Pharmaceutical Group, which produces China's first new crown vaccine, was interviewed exclusively by a reporter from China Voice of China.
(i) On the evening of December 30, 2020, the new crown inactivated vaccine of China Pharmaceutical Biologics Beijing Company was approved for conditional listing.
Zhang Yuntao and his team are getting busier.
Zhang Yuntao told CCTV China Voice that at present, China National Pharmaceuticals has started mass production of the new crown vaccine, the full-year 2021 production capacity is expected to reach 1 billion doses, this number can meet 500 million people vaccinated.
: "At present, the first phase of construction of our Beijing and Wuhan companies has been completed, with a production capacity of 120 million doses."
Beijing is accelerating the second phase of construction, which will be completed in 1-2 months, so that the entire 2021 Chinese bio-crown vaccine production capacity can reach 1 billion doses.
currently based on available data, it should be able to meet the vaccinations of 500 million people.
china's biocapacity we are continuing to improve to see if we can continue to do a little bit of optimization in capacity.
" it is understood that the domestic vaccination of the new crown vaccine for the whole virus inactivated vaccine, that is, through chemical and other methods to make the new coronavirus loss of infection and replication, while retaining the human immune response activity can be prepared for the vaccine.
Zhang Yuntao, an inactivated vaccine, is a traditional classical method of vaccine preparation and belongs to a mature, reliable and classical method of vaccine research and development.
Zhang Yuntao: "There are many inactivated vaccines, the most typical of which is the polio vaccine that a child is born with at the age of two months, and the EV71 vaccine, which was launched globally in Chinese in 2017, are inactivated vaccines.
, of course, in a broad sense, influenza vaccine, white vaccine, rabies vaccine, etc. belong to the category of inactivated vaccine.
addition to the viral culture and inactivation phases required for the new corona vaccine, which needs to be carried out in higher-level biosethic facilities, the process is largely consistent.
" vaccine is widely recognized as the terminator of the new coronavirus.
how long will the new crown vaccine be protected? Really not more than half a year? On the issue of public concern, Zhang Yuntao said it was too early to define a vaccine protection time because the new coronavirus discovery and clinical studies did not take long.
zhang Yuntao: "The new crown vaccine in China is April 12, April 13 and April 27 to obtain clinical research approval, to this day clinical research time is not long enough."
because our data are in the process of statistical analysis, from a medium and antibody perspective, the available data support six months of data, follow-up data is still under continuous observation.
" Zhang Yuntao said, want to final determine whether the new crown vaccine protection time is likely to last a year, at least 14-15 months of data. zhang Yuntao:
"must be in clinical trials someone to reach a year, take blood, but also to do the antibody test, testing and do statistical analysis and then form a report."
if you look at six months of data, it should actually take 8-9 months, and 14-15 months to see a year's data.
" to some people after the new crown vaccine, and then to the hospital to do antibody testing practices, Zhang Yuntao does not approve.
Zhang Yuntao: "As far as I know, many hospitals on the new coronavirus anti-medical reagents are not detected neutral antibodies, we are now talking about antibody persistence refers to neutral antibodies."
hospital testing reagents are testing for total antibodies, which also contains between antibodies.
total antibody refers to the production of a variety of antibodies, the middle antibody refers to the antibody can prevent the development of new coronary pneumonia.
The quality difference between some hospital reagents is still relatively large, so from the results of hospital testing, many hospital test results can not fully represent whether the production of antibodies or the presence of antibodies.
"many people are concerned that the mutant new coronavirus found in many countries may lead to a decline in vaccine effectiveness, thereby increasing the risk of infection between vaccinated people."
to this, Zhang Yuntao said, from the previous cross-protection tests, China Bio-Beijing's new crown vaccine has a broad-spectrum protection effect on strains from different parts of the world, the role of the recent British variant is currently being tested.
: "This time, china Bio-Beijing's new crown vaccine came on the market, and also carried out cross-examination and protection tests on new crown strains from different sources around the world.
from the data we got at the time, the new crown vaccine from China Bio-Beijing is now broad-spectrum protected and has a good crossover of strains from different parts of the world.
Because we did phase III clinical work in the UAE, where the number of people in the group is close to 50,000, there are 125 countries, from different parts of the world, this vaccine chose to conduct phase III clinical studies at this point, and the protective data obtained is broad-spectrum protective data.
, said the team had also recently observed new strains of mutant disease in the UK, which were being tested.
"to see how our vaccine protects this strain, and now we are testing the strain in the UK."
countries around the world are already starting to get vaccinated, so how is a foreign vaccine different from a Chinese biological vaccine? How to evaluate the quality of a vaccine? How to understand the efficiency of China's new crown vaccine 79.34 percent such a value? Zhang Yuntao said that China's biological vaccine and the world's more concerned about the design of the two vaccines are not the same principle, belong to different technical routes.
the technical route of China's bio-whole virus inactivated vaccine is widely used and widely accepted in the world.
: "Pfizer and Moderna are mRNA vaccines, vaccines that are an innovative technology route that has not been used in large populations and commercially.
From a design point of view, we in China's biological vaccine is a whole virus, mRNA vaccine is to use the human body as a vaccine factory, in the cytoste by translating antigens to stimulate the body to produce antibodies, there are some cellular immunity.
" Zhang Yuntao said, evaluating the quality of a vaccine has many factors, long-term safety and ability is very important factors.
: "Long-term safety needs to be observed, such as inactivated vaccines, and long-term safety has been verified, including in the United States and other countries around the world."
, we also need to look at vaccine effectiveness data, China's biological vaccine protection effectiveness is 79.34 percent, Pfizer and moderna is more than 90 percent, this is absolute effectiveness data.
, the effectiveness of the vaccine depends on the vaccination rate.
because the vaccine is the formation of an immune barrier to prevent the spread of the virus, to form an immune barrier against disease, vaccination rate is also very important.
both effects should go hand in hand, and efficiency and vaccination rate are two very important parameters.
, the storage need for vaccines is also a very important parameter, as this will directly affect the future popularity of vaccines.
Zhang Yuntao further explained that the new crown vaccine, which is too temperature sensitive, would be much more accessive and affordable.
Zhang Yuntao: "This is a vaccine used by all mankind, in the history of the world is very rare, vaccine access requirements are very high, such as transportation storage conditions are very high, foreign-listed BioNTech and Pfizer vaccine storage conditions are still relatively harsh, the requirements of -70 degrees C, -20 degrees C cold chain conditions in most parts of the world and countries are not available."
like the vaccine established in our country, cold chain transportation conditions are perfect, with a very good system of 2-8 degrees Celsius.
"how to understand the efficiency of China's new crown vaccine 79.34 percent such a value? Zhang Yuntao said that as a respiratory vaccine, this data is already a better effect.
Zhang Yuntao: "Now the world's listed vaccines, the efficiency of more than 90% is actually relatively small, such as hepatitis B, hepatitis A and other vaccines are more than 90%."
Especially some respiratory vaccines, in fact, the efficiency is relatively low, like we have to fight the flu vaccine every year, the efficiency is about 40% to 60%, so this time the World Health Organization to 50% as the final effective indicator of the new crown vaccine, but also because it is a respiratory virus.
combined with the efficiency of each vaccine, a respiratory vaccine is 79.34 per cent more efficient and is a very good result in the field of respiratory vaccines, not relatively general.
look at the quality of a vaccine, from a comprehensive perspective, safety, effectiveness, accessability, affordability.
vaccine safety data are very good.
We understand that the two vaccines listed abroad in addition to long-term safety has not yet obtained any data, in fact, in the short term its high fever rate, the degree of fever is much higher than inactivated vaccines.
so, our vaccine is still relatively good.
( 3) With the vaccination of new crown vaccines in key population groups in China, there are more and more questions about vaccinations, such as whether people under the age of 18 can be vaccinated. Is the new crown vaccine two or three or even four? At present, China is in the key population of the new crown vaccination, in which the population range is selected between 18-59 years old, then other age groups can also be vaccinated? When will I be vaccinated? Zhang Yuntao: "On the inactivated vaccine instructions for Chinese organisms listed on this market, we have marked the age group of 18 years old and above, including people over 60 years of age."
didn't include 3-17 years old this time? Vaccines for ages 3-17 are called infant and minor vaccines.
when we did the first and second clinical studies, we did 18-59 years old first, then 60 years old, and then 3-17 years old.
3-17 years old and it is classified as 12-17 years old, 5-12 years old, 3-5 years old three age groups to do, in fact, the entire vaccine is divided into five age groups to do.
3-17 years of age in the first and second clinical studies we have completed, the safety is still very good, but the source-free data is in the process of detection.
" Zhang Yuntao revealed that the vaccine will be expected to cover all ages 3 and older.
Zhang Yuntao: "In the future, we will communicate with the Drug Administration, based on the results of safety of 3-17 years old, immunologic results, neutral antibody results to continue to declare, the age group from 18 years old and above to 3 years old and above the full age group."
" according to the recommended immunization procedures, the new crown vaccine is generally 2 injections.
in order to "strengthen" the effectiveness of the epidemic prevention, can the 3rd and 4th new crown vaccine be injected? Zhang Yuntao: "If it is a very special variant, then you strengthen the 3rd and 4th needles are not functioning."
whether to strengthen the 3rd needle, to wait for the future antibody persistence data out, to determine what nodes, whether it needs to fight, at what point in time to play the appropriate.
that's when you can determine if you need to play and when it's appropriate.
" Zhang Yuntao said, from past experience, inactivated vaccines mostly need to be shot with a third shot, but often the third shot is used as a strengthening needle.
in a complete immune program, it is possible to get the first two injections.
zhang Yuntao: "In the short term, my personal point of view is that we do not need the 4th needle for the time being, at least we have to continue to observe the persistence of antibodies, to get scientific data, such as 1-2 years after the antibody dropped, the 4th needle is actually called strengthening the needle, strengthening immunity."
"CST China Voice Source: CST China Voice Copyright Notice: All text, pictures and audio and video materials indicated "Source: Mets Medicine" or "Source: MedSci Original" are owned by Metz Medical, are not authorized, and may not be reproduced by any media, website or individual, and shall be reproduced with the words "Source: Mets Medicine".
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
reproduce content at the same time does not represent the position of this site.
leave a message here