What is anticholinesterase inhibition.

asked: dragon sunflower alkali poisoning can resist cholinesterase inhibition, is it said to fight the role of cholinesterase decomposition of choline? Thus choline accumulation, resulting in symptoms of poisoning? So there is a drug to replace cholinesterase to break down choline, can be detoxifyed? So is the reason for the poisoning of dragon kwai alkali the same as that of snake poison? So do you have any such drugs that can play such a role? What is its chemical composition?
: 1, dragon sunflower alkali is alkaloid, is extracted from the whole grass or immature fruit of the aubergine plant dragon sunflower isolated alkaloid. There is a role in blocking cholinesterase activity, choline accumulation, gastrointestinal stimulation. Acute poisoning of the general food after the number of l0 minutes to several hours of morbidity.
first have a burning sensation in the mouth and throat, followed by nausea, vomiting, abdominal pain, diarrhea and other gastrointestinal symptoms. Light 1 to 2 days white, heavy can have elevated body temperature, convulsions, coma, breathing difficulties, palpitations, severe can be due to respiratory muscle paralysis and death.
2, detoxifying: (i) remove the remaining dragon kwai alkali;
3, cholinesterase: is a class of glycogen, in a variety of isoenzyme forms present in the body. Generally can be divided into true cholinesterase and false choline lipase. True cholinesterase, also known as acetylcholinesterase, mainly exists in choline-energy nerve ending synaptic gaps, especially in the wrinkled membrane of motor nerve end-plate synapses, but also in choline-energy neurons and red blood cells.
false cholinesterase is widely found in glial cells, plasma, liver, kidneys, intestines. The specificity of Ach is low, and the false cholinesterase hydrolyses other choline esters, such as amber choline.
currently does not have such a drug.
4, snake poison poisoning machine: the whole body action is mainly to inhibit the binding of acetylcholine and receptors (dragon sunflower alkali caused acetylcholine accumulation), nerve conduction blocking. There are also myotoxicity, clotting enzyme toxicity, protein dissolving enzymes and other aspects to achieve toxic effects.
: The symptoms of gloride poisoning are similar
the symptoms
of phosphorus pesticide poisoning in organic phosphorus. In addition, dragon sunflower base has a dissolving effect on red blood cells.
Detoxification using Athosin is proof therapy (blocking M-subject agitation symptoms), in organophosphorus pesticide poisoning N-subject agitation symptoms, must be combined with cholinesterase resuscitation agent (is a class of
compounds withstructure
, such as iodide phosphorus) to restore activity, reduce Ach content (to the treatment). P.S.: Dragon Kwai alkali poisoning doesn't seem to be resuscitation agent with cholinesterase.
The nature of snake venom is divided into three categories: neurovenomy (which mainly works on myelin and spinal nerve cells and blocks nerve joints, causing respiratory paralysis and muscle paralysis), and blood venom (which has a strong dissolved
tissue
, hemolytic or anticoagulant effect. Mainly composed
lysosin
and phospholipids), mixed poisons (both).
.