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    Home > What is cholesterol synthesis?

    What is cholesterol synthesis?

    • Last Update: 2020-04-03
    • Source: Internet
    • Author: User
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    Every cell in the body contains cholesterol, which is used to produce certain hormones, bile acids and vitamin D

    To ensure availability, the body itself provides a biochemical process called cholesterol synthesis

    More than half of the body's cholesterol needs are produced by cholesterol synthesis, which occurs daily in the gut and liver

    Cholesterol precursor cholesterol synthesis begins with acetyl CoA, a byproduct of the breakdown of proteins, fats and carbohydrates into cell energy

    The body has the ability to use acetyl CoA synthetase to start ethanol oxidation to produce acetyl coa

    Before cholesterol is finally produced by active enzymes, numerous enzymes participate in the reaction process

    The first involves acetyl CoA thiolase, which produces acetyl coa

    Reduction reaction Cholesterol synthesis continues to react with acetyl CoA, 3-hydroxy-3-methyl-coa and mevalonate

    Note, however, that statins such as Lipitor can interfere with cholesterol synthesis at this stage

    If not interfered with by statins, mevalonate is converted to isopentenyl pyrophosphate and then to squalene

    Squalene is eventually converted to cholesterol

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