What is glutathione deficiency?

Glutathione deficiency is a disorder that prevents the body from producing glutathione Glutathione is a molecule of three amino acids, which is necessary to maintain the normal function of human immune system Glutathione prevents cell damage by destroying harmful or unstable molecules in the process of energy It also helps to build DNA and proteins and plays an important role in dealing with drugs and carcinogens that are ingested into the body The disease is mainly caused by mutation or mutation of glutathione synthetase gene, and it is hereditary However, metabolic disorders such as diabetes and various congenital diseases may also lead to glutathione deficiency Glutathione deficiency occurs in three stages: mild, moderate and severe The initial symptoms of deficiency include vomiting, diarrhea, anemia and abdominal pain, which are similar to those of MS or vitamin B12 deficiency At the time of glutathione deficiency, a compound called 5-oxyproline accumulates in the blood, urine and spinal fluid Other symptoms include hemolytic anemia caused by red blood cells and metabolic acidosis Moderate deficiency symptoms are the same as mild symptoms, but more severe Severe glutathione deficiency involves neurologic disorders such as psychomotor retardation, characterized by physical response, delayed movement and speech Epilepsy, loss of coordination and mental disorders may also occur The more serious, the less common symptoms of bacterial infection may occur It is mainly used to correct metabolic acidosis with appropriate dosage of sodium citrate and citric acid, and antioxidant vitamin E and C to help treat glutathione deficiency Depending on the time of discovery, these methods can usually be used to repair glutathione levels Alpha lipoic acid and N-acetylcysteine are also used to treat this deficiency Alpha lipoic acid is a more effective antioxidant than vitamins E and C Although a rare disorder, glutathione deficiency is also a chronic and fatal disease Mild or moderate patients usually need to live under the supervision of doctors, while patients with severe deficiency are not very optimistic Even if the treatment measures are taken, the patients will still face serious problems such as mental retardation, epileptic seizures and nerve deterioration.