What is the cause of cisplatin resistance?

Cisplatin is a kind of cancer treatment drug, which can be provided to patients by medical staff as part of chemotherapy It should be known that long-term use of this drug will lead to drug resistance in human body, including the immunity of targeted cells to drug components, and the rejection of cisplatin by different molecules before they have the opportunity to play a role Because cisplatin tries to destroy DNA in cancer cells, the body will instinctively try to repair DNA destroyed in proteins, so it will reduce the effectiveness of drugs because some cells repair the damage caused by cisplatin In fact, drug resistance is also one of the main reasons for discontinuation of cisplatin during chemotherapy During months of treatment, the colorless liquid is injected into the body through the veins of the hand, arm or clavicle Cisplatin targets cancer cells such as testicular cancer, lung cancer and bladder cancer to prevent the spread of the disease in the body One of the reasons for cisplatin resistance is that cells have the ability to change their properties, to form an ability that does not allow drugs to penetrate and move in It is not clear why the drug failed to penetrate cancer cells, a process that reduces intracellular accumulation There is a theory that cancer cells need active help to get cisplatin through the outside, and after long-term use, this assistance will stop, leaving the drug out of the bloodstream without absorption To work effectively, cisplatin needs to act directly on the DNA of cancer cells, destroying it from within There are more molecules in cells than DNA that interact with drugs and exclude drugs, so as to exclude the chance of cisplatin resistance Detoxifying molecules in the body's cells help keep it healthy and eliminate pollutants Detoxification metallothionein excretes heavy metals from the inside of cells and can attract cisplatin Attracted by molecules, cisplatin is expelled before cancer cells have a chance to damage DNA Some proteins help repair DNA when exposed to chemotherapy drugs Cisplatin resistance can occur when these proteins are present in drug targeted cells After chemotherapy, the level of xpe-bf nuclear protein tends to increase with the long-term use of drugs, thus increasing the possibility of cisplatin resistance.