echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > What is the prospect of a bst? Science sub-journal reveals the mystery of alcohol addiction.

    What is the prospect of a bst? Science sub-journal reveals the mystery of alcohol addiction.

    • Last Update: 2020-07-29
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    A recent article published by Science Advances sheds light on the key mechanisms of alcohol addiction that offer hope to help people quit drinkingAn international team of researchers led by DrSantiago Canals of the Alicante Institute of Neuroscience in Spain found that alcohol can alter the geometry of gray matter in the brain, which in turn affects the spread of neurotransmitters, including dopamine, and perpetuates harmful effects, including addictiondoi: 10.1126 / sciadv.aba0154 Alcohol causes gray matter pattern changes in the brain, a report published in April 2019 in JAMA Proci, suggests that alcohol causes changes in brain white matter, leading to increased spread of the extracellular exophde of gray matter cells in the brain, and even if alcohol is stopped, alcohol can still damage the brainIn the new study, researchers uncovered key mechanismsdoi: 10.1001/jama-spirity.2019.0318 The researchers first analyzed the effects of alcohol on the average average diffusion rate (MD) of the brains of mice, and found that alcohol caused an increase in gray matter MD in the mouse brainAt the same time, similar patterns of change were observed in the human brain, and changes in the actual MD of the human brain with drinking disorder (AUD) were more pronouncedthe effects of drinking on gray matter MD in rats and human brains The extracellular gap (ECS) is an irregular and interconnected narrow channel present in interbrain tissue, which plays a key role in ensuring the stability of electrical signal transmission between brain cells, and the remodeling of nerve synapsesIn the study, the researchers found that drinking alcohol for one month led to significant changes in ECS properties, resulting in increased neurotransmitter concentrations that extended further into esCDopamine, which is associated with various addictive behaviors, is one of the neurotransmittersThe researchers believe it is this change that amplifies the pleasure that alcohol brings to drinkers and further encourages people to develop drinking habits and even eventually become addictedSmall glial cell changes enhance drinking preferences Previous studies have shown that the response of glial cells, including small glial cells and astrocytes, is a typical change in the brain that affects esC volumeSo, in further experiments, the researchers immuno-dyed and quantified the staining intensity of the two cells, and analyzed the morphological changes of the two cells within one month of drinkingThe results showed that small glial cells showed the strongest alcohol-induced responseAfter 1 month of drinking, the number of small glial cells decreased significantly and the staining intensity decreased significantly, indicating a decrease in branching and a reduction in diffusion barriersAfter a week of withdrawal, the staining intensity did not change, although the number of small glial cells was partially restoredthe response of small glial cells to alcohol, the researchers used two alternative methods to reduce the density of glial cells in the gray matter of the mouse brain The experimental results further proved that the small glial cell response was sufficient to cause an increase in alcohol-induced brain essential MD Overall, the study showed that regular drinking alters small glial cells in the brain, leading to a higher average spread rate of gray matter in the brain, leading to alcohol addiction in some people This opens the way for future researchers to develop treatments that can change and ultimately reverse these changes in the brain Related: the measurement method of extra-seofy smof-alcohol-alcohol-alcohol-space-geoy and daethin brain s2' the immune system seibodyr sizzle sizzle addiction s.3, and its physiological and pathological significance.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.