What p53 is and how it is related to DINO's lncRNA molecules.

What is p53 and its relationship to DINO's lncRNA molecules? Recently, researchers from Stanford University found that p53, a well-known cancer-suppressing gene, can be stabilized by a molecule called DINO lncRNA.
this interaction helps cells respond to DNA damage and may play an important role in the development of cancer.
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is p53? It is a cancer-suppressing gene.
p53 identifies and responds to DNA damage, enhancing a range of gene expression associated with DNA repair and cell differentiation.
when p53 mutates, it loses the ability to regulate cells' ability to respond to DNA damage.
p53 mutation is the most common cause of multiple cancers.
: DNA damage is a common natural product in cell division, after all, the genome contains 3 billion nucleotides, they can not be copied without a mistake.
exposure to certain chemicals, ultraviolet rays, and ionizing radiation can cause DNA damage.
DINO is part of a long chain of non-coding RNA (long non-coding RNA, lncRNA).
RNA, which is larger than 200 nucleotides, was initially thought to be the "noise" of genome transcription and did not have biological function.
In recent years, more and more studies have found that lncRNA plays an important role in many life activities, such as dose compensation effect, surface genetic regulation, cell cycle regulation and cell differentiation regulation, and has gradually become a hot topic of genetic research.
study is the first to verify that lncRNA plays an important regulatory role in the path of DNA damage in animals.
researchers found that DINO is an important component of the DNA damage response system on which p53 depends.
p53 enhances the expression of DINO, which in turn binds and stabilizes the p53 protein, forming a positive feedback loop that amplifies the damage signal in the nuclei.
when DINO expression levels increase artificially, cells respond to DNA damage even if the genome does not change.
, when DINO expression is suppressed, the cell's response to the p53 signaling path is weakened.
the relationship between p53 and DINO's lncRNA molecule? The researchers say p53 is always monitoring for potentially dangerous changes in the genome, which is really important for cells.
if any trivial change in the cell stops it from growing, it's obviously not good for cell survival.
loop consisting of DINO and p53 is more like a "filter" to ensure that the DNA damage response is activated after a certain threshold has been exceeded.
, dino expression allows cells to respond appropriately to DNA damage.
addition, DINO, as an RNA molecule, is produced in the nucleation of the cell, where p53 is activated.
that DINO can provide a faster and more accurate DNA damage response than proteins synthesized in cytones.
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