When can children's medicine become the focus again?

[China Pharmaceutical network industry trends] recently, there are more news about children's drugs, and problems such as drug safety, less special drugs for children, and less drug companies for children are mentioned again Experts said that the lack of drugs for children and the abuse of drugs for adults have led to a social problem of safe drug use for children, which needs to be solved by all parties However, the data mentioned in the recent report of Legal Daily is even more shocking: about 7000 children die every year in China due to improper use of drugs Before that, data also showed that among more than 6000 pharmaceutical enterprises in the country, there are only more than 10 professional children's drug manufacturers Among the conventional drugs, there are more than 3600 prescription drugs for adults, but there are only 60 special drugs for children, less than 1.7% A series of data not only reflect the current situation of children's drug market, but also hit the heart of parents Academician fan Daiming, vice president of the Chinese Academy of engineering, said that with the comprehensive implementation of the two child policy and the further expansion of the child population base, the problem of children's drug use will become more urgent According to the analysis of experts in the industry, there are three reasons for the problem of children's drug use: first, the policy is not matched, and the relevant system of supervision and use is lack of connection; second, the risk of clinical trial process is large, which affects the clinical development of new drugs; third, the degree of marketization of children's drug use is not high, the profit of drug enterprises is low, and the enthusiasm of production is not high In terms of policies, the state has actually issued a series of policies related to children's drugs, such as the notice on printing and distributing the second batch of encouraging research and development and declaration of children's drug list, and the State Council's opinions on reforming the review and approval system of medical devices for drugs, which mentioned the relevant data submitted by applicants such as children's special drugs and the implementation of data protection But these are far from enough Neither the drug administration law nor the measures for the administration of drug registration put forward special provisions for children's drug use At the recent 2018 China children's drug safety conference, sang Guowei, vice chairman of the Standing Committee of the Eleventh National People ' In terms of trials, new drugs are inherently risky, especially for children Moreover, the metabolism of drug absorption and distribution in newborns is very different from that in adults, and the risk of research and development will be further increased Therefore, this is also a major reason for the lack of drug development in children In terms of pharmaceutical enterprises, the author has learned that the number of pharmaceutical enterprises specializing in the production of drugs for children is still relatively small, and professional children's drug brands only have single digit manufacturers such as "little sunflower" In this regard, some experts suggest that to change the current situation, we should first let children's medicine break away from the wings of adult medicine, and become an independent system from the large family of adult medicine Scholars and experts participating in the 2018 China children's safe drug use conference also said that solving the problem of children's drug use is not a one-off task, nor a simple one-off task What is needed is the full participation and cooperation of relevant government departments, scientific research units, pharmaceutical enterprises and clinical institutions For parents, although the current situation of children's drugs has not been completely improved, attention should also be paid to the selection of drugs for children For example, we should pay attention to four aspects in the formulation of drug treatment: first, we should select drugs reasonably according to the characteristics of children's diseases, monitor the concentration of drugs in blood when conditions permit, and give drugs individually according to the results; second, we should strictly master the dosage, and make adjustments according to the specific conditions of children's age (day age, month age) and condition; The third is to choose the appropriate dosage form and administration method The administration method directly affects the absorption effect of the drug The dosage forms that are easily accepted by children are oral liquid, syrup, patch, suppository, etc.; after that, the drug treatment reaction should be closely observed Therefore, the government should improve the legal policy and system of children's medicine as soon as possible, and protect the safety of children's medicine It is reported that the regulations on drug use guarantee for children have been submitted to relevant departments and are expected to be promulgated in the near future In pharmaceutical enterprises, children are the future of our country Pharmaceutical enterprises have the responsibility and obligation to ensure the drug safety of children, actively develop children's drug products, and ensure the drug safety of children is an important mission of relevant pharmaceutical enterprises For parents, although the drug system for children has great defects, parents should also improve their safety awareness and make their children take drugs scientifically and reasonably according to the doctor's advice.