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    Home > Biochemistry News > Biotechnology News > When neurons act like a double-edged sword...

    When neurons act like a double-edged sword...

    • Last Update: 2022-05-19
    • Source: Internet
    • Author: User
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    A new study reports that immune cell responses to bacteria differentially affect the intrinsic excitability of neuronal cell subtypes in rats


    If a neuron can be viewed as a battery that stores and discharges, then its intrinsic excitability can be viewed as the battery's storage capacity


    Like all immune cells, microglia's role is to kill pathogens and infections, and their activity is thought to regulate the intrinsic excitability of neurons


    "For example, uncontrollable intrinsic excitability has been attributed to psychiatric disorders such as mood disorders," explains author Gen Ohtsuki from Kyoto University


    Current knowledge about neuronal regulation comes from experiments analyzing Purkinje cells


    The team observed that calcium-activated SK ion channels in pyramidal cells were regulated by microglia, as were Purkinje cells


    "The effect is quite the opposite," Ohtsuki noted


    Pyramidal cells appear to respond to the same cytokines — TNFα or tumor necrosis factor — secreted by activated microglia: one of the most common cytokines released by immune cells in response to infection


    However, differences in SK channel regulation resulted in lower intrinsic excitability in pyramidal cells and higher intrinsic excitability in Purkinje cells


    "The effects of microglia in one part of the brain should not be generalized to the whole organ," warns Ohtsuki


    Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex

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