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Quarantine for 6 days, reunite with the group for 6 days
.
Amylin (blue speck) in the medial preoptic area disappears after isolation and returns after reuniting with the population
As we have experienced during the COVID-19 pandemic, loneliness or perceived social isolation is a major stressor for social animals and increases the risk of various mental and physical health problems such as depression, substance abuse , obesity and premature death
.
To understand the neural basis of loneliness, Kansai Fukumitsu and others at the Riken Center for Brain Science (CBS) in Japan discovered a molecular indicator and regulator of social isolation in female mice
Previous research by the RIKEN CBS group led by Kumi Kuroda has shown that in mammals, the drive for maternal care also comes from MPOA
.
Specifically, amylin-responsive neurons in the central MPOA (cMPOA) are required for maternal motivation
This observation led to a new study examining behavioral and neural responses to social isolation and social reunification in female mice
.
The researchers found that the six-day isolation resulted in an almost complete disappearance of amylin, which returned to normal after the mice were reunited with their caged companions for two weeks
.
This was true even when mice were separated by a windowed partition within the same cage, suggesting that female mice require free physical contact with other mice to maintain amylin expression in cMPOA
The researchers then carefully ruled out the possibility that amylin levels were affected by other factors, such as boredom, general stress, physical contact with humans, or contact with other mice for defensive purposes
.
They also found that amylin-expressing neurons in cMPOA were inhibited when dissociated and activated when they reunited
When the female mice were separated by a windowed partition, they first bit hard on the fence on the partition
.
This biting behavior was only observed when other mice walked through the divider, so the mice looked like they were trying to break the window and reunite with the other mice
Since the time of Darwin, scientists have hypothesized that social relationships among adults originally evolved through parental upbringing
.
This study provides molecular evidence to support this idea
Magazine
Nature Communications
DOI
10.
