Who sharing new crown research: the protection of medical staff with atypical children's symptoms needs to be strengthened

Recently, the official website of the World Health Organization has provided the global research database of new coronavirus disease (covid-2019), continuously collecting, compiling and sharing the latest scientific discoveries and knowledge about covid-2019 In today's article, the content team of Wuxi apptec collates the latest case reports, clinical features and epidemiological studies recommended by the World Health Organization on February 17 DOI: 10.1038/d41586-020-00154-w On February 15, the Ministry of health of Egypt and the World Health Organization said that the first new crown case in Africa was found by tracking tourists from the epidemic affected areas The patient's nucleic acid test was positive but there was no relevant symptom At present, it is being isolated and the condition is stable Researchers are concerned about the risk of the new coronavirus being imported into Africa and spreading At a recent meeting in Munich, Dr Tan Desai, Director-General of the World Health Organization, said of the new coronavirus epidemic (see today's three reports for details), "the most worrying thing is that the virus epidemic may spread to countries with weaker medical systems." DOI: 10.3760/cma.j.issn.1671-0282.2020.0001 A comparative study of lopinavir / ritonavir (LPV / R) and placebo / standard therapy in patients with severe acute respiratory syndrome (SARS) and Middle East syndrome (mers) was conducted A total of 230 potential related articles were retrieved and finally included in four studies, including two cohort studies for SARS patients, one case report and one treatment guide for mers patients The results showed that the early application of LPV / R drug regimen could reduce the mortality rate of SARS patients and the dosage of glucocorticoids, which was of great significance to control the complications in the later period of treatment The team proposed that LPV / R can be used as an experimental therapy to explore and test the clinical effect of antiviral therapy for 2019 ncov pneumonia (especially for new infections) DOI: 10.3390/jcm9020538 The study, conducted by a team from Hokkaido University School of medicine and Japan's Department of science and technology, collected confirmed cases and deaths including those reported outside Wuhan as of January 31, 2020 based on public information Based on the three key dates of symptoms, admission and death, the model estimates that the incubation period is 2-14 days, with an average incubation period of about 5 days The average time from symptom onset to admission is about 3-4 days If considering the potential impact of non real-time data as of January 31, it is estimated to be 5-9 days The median time from symptom to death was 13 days (17 days considering the effect of the deadline) DOI: 10.3760/cma.j.issn.0578-1310.2020.0007 In this study, the clinical data of 15 children with new coronavirus infection (positive initial detection of nucleic acid) admitted to the third people's Hospital of Shenzhen as of February 6 were analyzed retrospectively There were 5 males and 10 females aged 4-14 years Fever was found in 5 cases and asymptomatic in 10 cases There were 6 cases with no pathological changes in the initial chest CT image, 9 cases with pulmonary inflammation, including 7 cases with small nodule ground glass shadow and 2 cases with spot ground glass shadow After 3-5 days of treatment, reexamination: 6 children's nucleic acid turned negative, 2 cases of chest CT inflammation decreased, 3 children's chest still had no focus, 1 case had no obvious change; 9 patients were still nucleic acid positive, 6 cases of chest CT inflammation showed no obvious change, 3 cases reexamined chest CT showed new inflammation, all of which showed small nodule ground glass shadow The team suggested that novel coronavirus infection in children was not typical Early imaging showed small nodular ground glass opacity It is very important for children to have dynamic examination of chest CT and viral nucleic acid DOI: 10.3760/cma.j.issn.1001-0939.2020.0016 The clinical data of 30 patients with infection in the Affiliated Hospital of Hanjiang University in January 2020 were analyzed Among them, there were 22 doctors and 8 nurses, with an average age of 35 years Novel coronavirus pneumonia patients were contacted at close range (within 1 meters) The most common clinical symptoms were cough (83.33%), fever (76.67%), fatigue or general pain (70%), followed by headache (53.33%), dyspnea (46.67%), nausea, vomiting or diarrhea (30%) There were 7 cases with abnormal liver function and 5 cases with myocardial injury On the imaging manifestations, the main manifestations of chest CT were multiple small spot films and interstitial changes, including 11 cases of single lung involvement and 19 cases of double lung involvement, of which 4 cases showed typical diffuse ground glass changes Among 30 cases of infection, 26 were common type and 4 were severe type Compared with the common patients, the average contact times and cumulative contact time of the severe patients and the new crown patients were more, the BMI, the average heat range, the white blood cell count, the liver enzyme, the lactate dehydrogenase, the muscle enzyme and the D-dimer were significantly higher, the peripheral blood lymphocyte count and the albumin level were significantly lower Compared with those in the protective period, the proportion of severe cases in the unprotected period increased, and the number of patients with bilateral lung involvement increased Therefore, strengthening the protection is an important measure to prevent the infection of medical staff.