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    Home > Biochemistry News > Biotechnology News > Whole genome sequencing of 175 Mongols revealed the genetic structure of a particular population.

    Whole genome sequencing of 175 Mongols revealed the genetic structure of a particular population.

    • Last Update: 2020-08-07
    • Source: Internet
    • Author: User
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    Gene sequencing technology has given humans a deeper understanding of genetic diversity, but the number is still limited from the Mongolian genetic data collected so far.
    to solve this problem, Bai Haihua and his team of the School of Life Sciences of Inner Mongolia National University performed genome-wide sequencing on 175 Mongolians to reveal the genetic structure of Mongolians, and the results of the study were published in Nature-Genetics on November 6 under the title "175 Mongolians' whole genome sequencing reveals the genetic structure of a particular population".
    about 1000 years ago, the Mongolian empire expanded, the Mongolian rule of the territory was north to Russia's Siberia, south to the South China Sea, northeast to Heilongjiang, southwest to Myanmar Thailand, the Mongolian people also scattered around.
    currently has about 10 million Mongolians living in northern China, Mongolia and southern Russia.
    however, it is not known how the Mongolians affect the genetic structure of other regions and other ethnic groups.
    the study selected 175 samples from six different tribes/regions from northern China and Mongolia, including Abajas, Kalla, Orat, Buryat, Sonnid and Hochin, of which 72 were male and 103 were female.
    all of the samples were both Mongolian and Mongolian as the first language.
    the study collected peripheral blood from a sample to obtain genomic DNA and sequenceite, resulting in a total genome sequence of 11724 gigabits (Gb).
    researchers combined the genome sequence with the Thousand Human Genome Project to determine the genetic relationship between Mongolians and other ethnic groups.
    study found that the differences between the Abacha, Kharha, Orat and Sontide tribes were minimal, with Mongolian tribes having a greater degree of division than other East Asians, and a small amount of differentiation between Mongolians and mixed-race Americans.
    this fills the genetic "gap" between Native Americans and East Asians.
    studies have further shown that there is a large amount of genetic fluidity between the populations of northern Eurasia, with a closer bond between the populations of northern, eastern and southeastern Asia.
    the study is an important and timely complement to the global gene catalog, laying the foundation for the genetics of East Asians, providing basic information for understanding the genetic variants common to Mongolia and individual genetic variation, and making it possible for Mongolians and related populations to benefit from precision medicine.
    it is understood that the study has been reviewed under the guidance of the Ministry of Science and Technology and approved for human genetic resources.
    all participants agreed to use their genomic data in writing.
    Source: Science.com
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