Why do people get blessed as soon as they reach middle-term? Middle-age obesity is affected by enzymes in DNA-PK.

SCIENTISTs at the NIH in the United States have found an enzyme molecule that may be linked to middle-age obesity in a new study that promises to help find new drugs to combat middle-age obesity.
people get blessed as soon as they reach middle-term? "It is generally accepted that weight gain and lack of exercise in middle age are mainly due to poor lifestyle habits and lack of willpower, but this study shows that there are genetic factors involved, an overactive enzyme that promotes weight gain in middle age and affects athletic ability.
, " says Dr. Jay H. Chung, author of the paper.
used mouse models to test the role of this enzyme molecule in obesity and motor capacity.
They used an inhibitor that blocked enzyme activity in mice on a high-fat diet and found that the mice lost about 40 percent of their body weight. The study was the first to link the enzyme's activity to aging and obesity, the study was published in the international academic journal Cell Metabolism.
have long noted that it becomes increasingly difficult to lose weight and maintain exercise when people reach the age of 30 to 40.
scientists have developed new treatments for weight loss, but many have failed, largely because of a lack of understanding of how obesity occurs in middle age.
researchers tested bio-chemical changes in models of mice in middle age and found that an enzyme called DNA-PK increased activity with age.
further work shows that DNA-PK promotes the conversion of nutrients to fat, reducing the number of mitochondrials and other tiny cells that turn fat into energy.
the mitochondrial content of young people and the elderly body mitochondrial experience greatly reduced.
the number of mitochondrials can promote obesity and impair exercise.
researchers believe that inhibiting DNA-PK activity may reduce fat accumulation and increase the number of mitochondrials to promote fat burning.
They validated the theory by giving oral a DNA-PK inhibitor drug that, in addition to preventing weight gain in mice, increased mitochondrial content in skeletal muscle, enhanced aerobic activity in obese and middle-age mice, and reduced the risk of obesity and type 2 diabetes.
this study shows that DNA-PK is an important driver of decreased metabolic levels and motor ability during age, and found that this mechanism is very important for improving public health.
also opened the door to the development of new weight-loss drugs.
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