Why do people sleep?

Humans sleep a third of their lives, including invertebrates such as flies, worms and even jellyfish

When we are awake, the steady-state sleep pressure in the body will increase.

Zebrafish's neural activity characteristics during sleep are similar to those of humans, and they are the subject of sleep research

The study also found that it takes at least 6 hours of sleep to reduce steady-state sleep stress and repair DNA damage

So, what mechanism in the brain tells us: it's time to sleep? Studies have found that PARP1 protein is part of the DNA damage repair system and is one of the first proteins to respond quickly

Through genetic and pharmacological manipulation, PARP1 overexpression and knockdown (down-regulation) experiments show that increasing PARP1 can not only promote sleep, but also increase sleep-dependent repair

This new discovery describes how to explain the "event chain" of sleep at the single-cell level