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Original title: Why do some people only eat vegetarian blood fat is also high?
why do some people only eat vegetarian blood lipids are also high? Why do some people eat a lot of meat instead of blood lipids normal? Professor Song Baoliang, Dean of the School of Life Sciences of Wuhan University, answered the relevant questions with his research results on "the mechanism of eating induced cholesterol synthesis and the discovery of new drug targets for fat reduction". On the 17th, Changjiang Daily reporter learned from Wuhan University that the results were selected as the results of the 2020 "Top Ten Progresses in China's Life Sciences" announced by the Chinese Association of Science and Technology Life Sciences Association.
cholesterol is an essential lipid for life's activities, but too much can cause cardiovascular disease. When people eat carbohydrates, cholesterol is mainly obtained by their own synthesis. Synthetic cholesterol consumes a lot of energy, so mammals only increase synthesis after eating, and suppress it when hungry, a mechanism that has long been unclear.
, Song Baoliang led the team found that after eating carbohydrates, elevated glucose and insulin in the blood prompted the liver USP20 protein to be modified with phosphorylation, USP20 stable cholesterol synthesis pathway speed limit enzyme HMGCR, thereby raising cholesterol synthesis. Inhibits USP20, reduces blood lipids, loses weight, and increases insulin sensitivity. The findings not only reveal the body's nutritional induction mechanism, but also prove that USP20 can be used as a target for the development of new fat-lowering drugs. The results of this research and its application will benefit the health of all.
The Chinese Association of Science and Technology Life Sciences Association has been conducting the annual "Top Ten Progresses in China's Life Sciences" since 2015, with the aim of promoting life science research and technological innovation, and fully demonstrating and publicity the major scientific and technological achievements in the field of life sciences in China. At present, the selection activities have been carried out for 6 consecutive years. The selection continues the way in which project results are recommended and selected in the categories of knowledge innovation and technological innovation, recommended by the organization's member societies, selected by senior experts in the fields of life sciences, biotechnology and clinical medicine, and reviewed by the Bureau of the Joint Body of the Chinese Association of Science and Technology Life Sciences, and finally determined that 8 knowledge innovation categories and 2 technological innovation categories were selected.