Why do Tibetans survive at high altitudes? The elevation inflection point of hemoglobin concentration in Tibetan population.

Recently, the Kunming Institute of Zoology of the Chinese Academy of Sciences, in cooperation with the University of Tibet, Qinghai Plateau Medical Science Research Institute, etc., found that the Tibetan population haemoglobin concentration of the elevation inflection point.
Thin this is another stage of the team's research on the adaptation mechanism of the Tibetan plateau, the first time that 4500 meters may be the critical altitude of the Tibetan population to adapt to the low oxygen environment of the plateau, and initially answered the question of whether the Tibetan population can adapt to the high altitude."
the study was published online June 7 in the American Journal of Hematology (doi: 10.1002/ajh.24809).
Tibetan population living in the Qinghai-Tibet Plateau can better adapt to the extreme environment of low oxygen in the plateau.
compared with the Han people of the plains who migrated to the plateau, the Tibetan population living in the plateau showed a higher physiological intake, lower pulmonary arterial pressure and relatively low hemoglobin concentration.
, hemoglobin concentration can indirectly reflect the population's adaptation to the plateau.
Cebu Bing Laboratory and Cui Chaoying Laboratory of the Plateau Medical Research Center of the University of Tibet, Wu Tianyi Laboratory of Qinghai Plateau Medical Science Research Institute, etc., through more than 10 years of close cooperation, went deep into local villages and towns, collecting the blood and physiology of Tibetan populations at different altitudes in more than 20 geographical areas. Data on biochemical indicators, covering the Tibetan population from the lowest altitude (Mot County, 1,900 meters) to the extreme high altitude (Puma Jiangtang Township, Longkal County, 5,018 meters).
the detection rate of hemoglobin concentration and red blood cell growth in Tibetan populations changed with altitude.
A, hemoglobin concentration;
dotted line indicates a rapidly rising elevation inflection point in the population between hemoglobin concentration and red blood cell growth detection.
researchers systematically analyzed the pattern of hemoglobin concentration in these Tibetan populations with altitude changes, and found that the detection rate of hemoglobin concentration and erythropoietin in Tibetan populations was an inflection point at about 4,500 meters, showing rapid growth above 4,500 meters.
results suggest that the Tibetan population may no longer be effective in the extreme high altitude and low oxygen environment above 4500 meters by regulating the concentration of hemoglobin to adapt to the low oxygen environment of the plateau.
Zhang Hui, the first doctoral student at the University of Tibet, The Ph.D. student of Kunming Animal Institute of the Chinese Academy of Sciences and Yao Xi, and Cui Chaoying, a professor at the University of Tibet, were the co-authors of the paper, and Yu Bing, a researcher at the Kunming Institute of Zoology, and Yu Xuebin, an associate researcher, were the co-authors of the paper.
The research was funded by the Pilot B Project of the Chinese Academy of Sciences, the National Natural Science Foundation of China's "Micro-Evolution" Major Research Program and the Regional Science Fund, the Ministry of Science and Technology's "973" Program, and the Everest Scholars of the University of Tibet.
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