Why does everyone feel different in pain? Genetic variation can affect pain differences.

When seeking medical attention, the most complained symptom is pain.
people experience pain, endure pain, and respond to it differently, making it difficult for doctors to know how to treat each patient effectively.
why does everyone feel different lying in pain? All the pain we experience in our lifetimes comes from genes that make us more sensitive or less sensitive to pain, the American Fun Science website reported recently.
however, our mental and physical conditions, past experiences of pain and trauma, and circumstances all adjust our responses.
If you can better understand the various situations, what makes individuals more sensitive to pain or less sensitive, it is easier to develop personalized pain treatment to alleviate people's suffering.
, this personalized treatment reduces the risk of substance abuse, misuse and tolerance.
different human pain genes vary with the help of human genome sequencing technology, we have a lot of understanding of the number and location of the genes that make up the human DNA code, and we have discovered millions of tiny mutations in these genes.
these variations take many forms, but the most common is single nucleotide polymorphism (SNP), which represents a single difference in each unit that makes up THE DNA.
there are about 10 million known SNPs in the human genome: a person's SNP combination makes up his DNA code and is different from others.
is called a mutation when an SNP is common, and when an SNP is rare, it is called a mutation when it is found in less than 1% of the total population.
increasing evidence that dozens of genes and variants determine our pain sensitivity, the extent to which analgesics such as opioids reduce pain, and even our risk of chronic pain.
in the 1960s, it was reported that the families of some people with strong pain tolerance were genetically linked.
there was no technology to determine the cause of the disease, but we know from these rare families that congenital pain insensitivity is due to specific mutations or deletions of individual genes needed to transmit pain signals.
most common is one of the few SPPs in the SCN9A gene, which encodes the protein channels necessary to send pain signals.
this is rare: only a few cases have been documented in the United States.
it may seem a blessing to not feel the pain, but families must always be alert to serious injury or fatal illness.
usually, children cry after they fall, but people with the disease do not feel pain, and cannot distinguish between knee bruises and fractures of the tibia.
insensitivity to pain means that you don't feel chest pain that indicates a heart attack, lower right lower right abdominal pain as a sign of appendicitis, and so on, so it can have fatal consequences before the problem is detected.
the SCN9A gene variant not only causes people to be insensitive to pain, but also causes two serious diseases characterized by extreme pain: primary erythema and hyperactive extreme pain.
in these cases, mutations in the SCN9A gene will cause more pain signals than normal, but these types of inherited pain conditions are very rare.
however, as the public increasingly embraces genomic medicine and demands more precise personalized health care strategies, researchers are translating these findings into personalized pain treatments that match patients' genes.
genetic variation affects pain differences We know that scientists have been trying to "identify" the main and new genes that affect pain perception.
The SCN9A gene is the primary participant in controlling the body's response to pain by activating or silent sodium channels, but whether it amplifies or relieves pain depends on the mutation seamount to the individual.
Scientists estimate that up to 60 percent of the pain difference is the result of genetic factors, meaning pain sensitivity is transmitted through normal genetic inheritance in the family, just like height, hair color or skin color.
it turns out that SCN9A also plays an important role in the pain of normal people.
, such as the relatively more common SNP "3312G-T" in SCN9A, appears in 5 per cent of the population, which determines the patient's sensitivity to pain after surgery and how many opioids are needed to control it. Another SNP in the
SCN9A gene is more sensitive to pain caused by osteoarthritis, lumbar disc removal surgery, amputation of limbs and pancreatitis.
find alternativeways to find better pain relief in the treatment, we have been using local anaesthetic (including Lidocain, etc.) to treat pain by inducing short-term blocking of the channel to stop pain transmission.
more than a century ago, these drugs have been used to safely and effectively prevent pain.
But now, scientists have decided to find other ways to relieve pain.
interesting, researchers are evaluating puffertoxins.
this is a powerful neurotoxin produced by marine organisms such as pufferfish and octopuses, which works by stopping the spread of pain signals and is a potential painkiller.
these toxins have shown early efficacy in treating cancer pain and migraines.
we now recognize that, in addition to opioids, we need more accurate pain treatment tools that treat pain at the source and reduce side effects and risks.
by understanding the genetic causes of pain sensitivity and susceptibility to chronic pain and even analgesic responses, we can design better treatments to better address the "why pain" problem? Humans will benefit greatly only when we learn more about pain, which varies from person to person.
Source: Science Daily.