Why does the absence of silk polymer proteins in the skin cause eczema?

For the first time, scientists have pinpointed the cause behind a piece of eczema skin disease (special dermatitis), which can help us fight the chronic disease.
as early as 2006, researchers found a positive clue to a link between a person's lack of a skin protein and a risk of eczema.
now, scientists have based these results on bringing us closer to curing eczema.
eczema is a common skin disease that affects up to 20 percent of children and 3 percent of adults worldwide.
although there is no shortage of creams and wipes to relieve eczema symptoms, we still can't find a cure for it completely.
why is the absence of silk polymer proteins in the skin causing eczema? Over the past decade, scientists have known that eczema is associated with the absence of silk polymer proteins in the skin.
this protein can help shape human skin cells and give our skin an important barrier function.
if a person's genetic mutation prevents him from producing silk polymer proteins, he or she will develop skin diseases such as eczema and common fish scale disease (skin cells do not fall off, but are stacked with fish scales).
, researchers were unable to determine how people develop eczema when they lack silk polymer protein.
now, scientists from the University of Newcastle in the UK have teamed up with GlaxoSmithKline to track down a range of molecular pathfours that cause this unbearable skin disease.
the study was published recently in the Journal of Perverted Response and Clinical Immunology.
lead researcher Nick Reynolds, from the University of Newcastle, said: "For the first time, we have found that the absence of silk polymer proteins is enough to alter the key proteins and path pathrapies that cause eczema.
to study these mechanisms, the team used a laboratory-synthetic 3D living skin equivalent model.
changed the top layer of the lab's skin to lose the silk polymer protein, just as a genetic mutation occurs in the human body.
found that the defect was enough to trigger a series of molecular changes in the important regulatory mechanisms in the skin.
this affects cell structure, barrier function, and even causes cell inflammation and how to cope with stress.
"It is worth noting that we have identified significant changes in 17 proteins since the absence of silk polymer proteins in the live skin equivalent model for the first time," the team wrote in the paper.
then verified their initial findings by analyzing human skin samples.
comparing the skin conditions of eczema patients with healthy subjects, they found that some proteins in eczema patients had the same changes -- as laboratory models have shown.
is only a jigsaw puzzle in the eczema puzzle, but for past research can be described as the most promising progress.
once scientists know what's going on in the skin of a silk polymer protein gene defect, they can find a drug for the disease.
This type of study allows scientists to develop eczema drugs that can cure both the disease and the body, not just relieve its symptoms," Nina Goad of the British Association of Dermatologists said in a press statement.
"If you have eczema, this is very exciting news!"