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    Home > Active Ingredient News > Immunology News > Why is there an obvious correlation between the intestinal flora and the occurrence of a variety of autoimmune diseases?

    Why is there an obvious correlation between the intestinal flora and the occurrence of a variety of autoimmune diseases?

    • Last Update: 2021-03-24
    • Source: Internet
    • Author: User
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    February 24, 2021 // --The human body’s immune system is very powerful and complex.


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    Image source: pursuit.


    The results of the study of twins show that factors such as lifestyle or environment play a key role in the occurrence of autoimmune diseases.


    Salt

    Salt

    Previously, researchers Kleinewietfeld and others have found through research that a high-salt diet can affect the body’s immune system, including the cells responsible for inflammation.


    Researchers have found that a high-salt diet specifically eliminates beneficial microbial communities in the intestines, such as lactic acid bacteria, which is the most common friendly bacteria in the body’s intestines.


    metabolite

    metabolite

    Researcher Kleinewietfeld said that close observations found that lactic acid bacteria can inhibit the function of the immune system by releasing metabolites.


    At present, this research is still in the early stage.


    Intestine

    Intestine

    The cause of this disease is currently unknown to researchers, but there are indications that there may be a correlation between changes in autoimmune properties and the microbiome.


    Part of the answer to this question may come from studying the situation of patients after transplantation.


    Image source: Lumen Learning

    Fecal transplant

    Fecal transplant

    If they can find the metabolites that drive the disease, the researchers hope they can start a new study to test the effects of therapies on changing the balance of the intestinal microbiome, such as probiotics or stool transplant therapy.


    It is this hope that has prompted more scientists to begin to study the key role played by the microbiome in the occurrence of diseases.


    Reference materials:

    Reference materials:

    [1] Sodium Chloride Drives Autoimmune Disease by the Induction of Pathogenic Th17 Cells

    Sodium Chloride Drives Autoimmune Disease by the Induction of Pathogenic Th17 Cells

    【2】europa.


    europa.


    Salt-responsive gut commensal modulates TH17 axis and disease

    [4] ncbi.


    ncbi.


    europa.


    com/news/2021-02-gut-bacteria-key-autoimmune-diseases.
    html">Why gut bacteria are becoming key suspects in autoimmune diseases

    by Ian Le Guillou, Horizon Magazine, Horizon: The EU Research & Innovation Magazine

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