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    Home > Active Ingredient News > Endocrine System > Wonderful review of Food Frontiers: Research progress and opportunities of dietary polyphenols as hypoglycemic drugs

    Wonderful review of Food Frontiers: Research progress and opportunities of dietary polyphenols as hypoglycemic drugs

    • Last Update: 2021-10-21
    • Source: Internet
    • Author: User
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    Chongde Sun (), Chao Zhao (), Lei Chen* (), Jianbo Xiao () and others published a review article entitled "Dietary polyphenols as antidiabetic agents: Advances and opportunities" in Food Frontiers
    .

    This paper systematically reviews the overall mechanism of a variety of dietary polyphenols regulating sugar metabolism and the latest progress in clinical trials, providing new insights for nutritional intervention in the changes and regulation of sugar metabolism and innovative dietary polyphenol nutrition and health foods
    .

    Introduction to the results Figure 1 Dietary polyphenols hypoglycemic mechanism Polyphenols are the most common plant-derived bioactive compounds in our daily diet.
    They are widely found in various foods, including fruits, spices, seeds and vegetables
    .

    More and more studies have confirmed the health-improving effect of dietary polyphenols.
    Since 2010, research on "polyphenols and diabetes" has increased significantly.
    As potential anti-diabetic drugs, polyphenols have been used clinically in cells, animals, and humans.
    The level of testing has received extensive attention
    .

    Figure 2 The effect of polyphenols and intestinal flora on diabetes Activate insulin signals, stimulate the pancreas to secrete insulin, inhibit glucose absorption, inhibit digestive enzymes, regulate the intestinal microbiota, improve inflammation, and inhibit the formation of advanced glycation end products
    .

    Dietary polyphenols can improve diabetes complications, such as vascular dysfunction, nephropathy, retinopathy, neuropathy, cardiomyopathy, coronary heart disease, and renal failure
    .

    In addition, this article summarized the effects of dietary polyphenols and their metabolites in the intestinal flora on improving type 2 diabetes, and that hyperglycemia status significantly affects the bioavailability of dietary polyphenols
    .

    Studies have found that resveratrol, curcumin and anthocyanins have significant anti-diabetic activities in human studies
    .

    Further research should focus on the structure-activity relationship of polyphenols' anti-diabetic activity and how hyperglycemia affects the bioavailability and biological activity of dietary polyphenols
    .

    Figure 3 Dietary polyphenols improve diabetes complications related reading: Food Frontiers latest research hot articles, free reading Food Frontiers | MRI metabolomics analysis of dried lemon slices during storage, Food Frontiers special issue focuses on research on berry fruits promoting health, invites You read for free Wiley promotes world progress and development with scientific research and education
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