Working principle and process of experimental boiling granulator

Boiling granulator (commonly known as one-step granulator in China) is a product developed abroad It has been introduced in China since the early 1970s and has been used in pharmaceutical factories for nearly 40 years Compared with other wet granulation methods, boiling granulation technology is a technology that integrates mixing, granulation and drying in a totally closed container Compared with other wet granulation methods, it has the advantages of simple process, short operation time, low labor intensity, and reduces the number of material handling times and the time required for each process, so as to reduce the pollution of materials and the environment Boiling granulation technology has the advantages of fast heat transfer, high heat transfer efficiency, uniform particle size, small density, good fluidity and good compression formability There is little or no migration of soluble components between particles, which reduces the possibility of uneven tablet content The experimental fluidized bed granulator is a multifunctional fluidized bed with the functions of top spray and bottom spray It has many functions such as mixing, drying, granulating, coating and so on It is widely used in pharmaceutical, food, chemical and other industries The granulator is a new model developed by our company, which widely absorbs and digests foreign advanced technology and combines with national conditions Reasonable structure, stable performance, convenient operation, no dead angle and no exposed screw The machine adopts PLC full-automatic control, and all operations are completed automatically according to the process parameters set by the user, which fully meets the GMP requirements of drug production The main features are as follows: 1 It integrates mixing, drying, granulating and coating, which can directly dry liquid materials, and has many functions such as rapid drying of particles, powdery materials, granulating and coating 2 The equipment works under the closed negative pressure, and the internal surface of the whole equipment is bright and clean, without dead angle, easy to clean, meeting the requirements of "GMP" 3 PLC + touch screen control is adopted, all operations can be completed automatically according to the set parameters, and the process data can be recorded for analysis Working principle and process of the equipment: the equipment is composed of air inlet system, fluidized bed system, top spray system, bottom spray system, air outlet system, control system, etc The top spray is for granulation and drying function, and the bottom spray is for coating function The above functions are all realized on the same multi-functional fluidized bed Users can select and match the functions according to the actual production process The powder material is put into the closed container of the hopper Due to the effect of hot air flow, the powder is suspended and circulates in a fluidization form to achieve uniform mixing At the same time, the powder in the container is sprayed with a mist like binder to wet the powder, so that the powder can be condensed into loose small particles At the same time, as the hot air flow dries the powder, the water evaporates continuously, the powder solidifies continuously, and the process is repeated to form a mechanism Want, even microporous spherical particles, in a container to complete the mixing, granulation, drying three processes The results were tested by t-test with the water content and disintegration time of the solid preparation as the index Results: when the solid preparation was dried, there was significant difference between the boiling drying method and the traditional drying method The above is what I want to share with you today I hope it will be helpful for you to use this equipment in the future.