World J Gastroenterology: Nutritional status and nutritional support for the role of chronic chronic liver failure associated with the hepatitis B virus.

Liver cell function can not meet the physiological needs of the human body is liver failure, it is clinically common serious liver advanced lesions.
, liver failure associated with hepatitis B virus (HBV) is an important issue worldwide.
HBV infection levels in China are high, HBV-related chronic liver failure (HBV-ACLF) is also a major medical burden.
Due to inadequate nutritional intake, abnormal liver structure and malfuncation, HBV-ACLF patients' condition leads to impaired nutrient synthesis and absorption, while malnutrition can further aggravate liver damage and affect quality of life and survival time.
currently, the majority of people with malnutrition with liver disease are slow to progress, more attention should be paid to nutrition risk screening and appropriate nutritional support.
, however, in the past, the treatment of chronic liver failure relied too heavily on drugs and artificial liver support, ignoring basic nutritional support.
gastrointestinal tract is not only involved in digestion and absorption, but also has important barrier functions, and damage to the intestinal barrier can be seen in animal models of liver failure, indicating that liver damage will further aggravate damage to intestinal function.
, this study aims to investigate the nutritional risk and nutritional status of HBV-ACLF patients and to assess the impact of nutritional support on the gastrointestinal barrier and 28-day mortality.
researchers compared nutritional risk screening results and gastrointestinal barrier biomarker levels in HBV-ACLF patients (n s 234) and cirrhosis compensation period patients (control group) (n s 234) between 2016 and 2018.
the same analysis of HBV-ACLF patients after nutritional support has been provided.
results compared the difference in survival rates of HBV-ACLF patients with nutritional support (n s 234) or no nutritional support (2014-2016) (n s 207).
results showed that the nutritional risk was significantly higher in HBV-ACLF patients than in the control group, while the nutritional intake in HBV-ACLF patients was lower than in the control group.
decreased skeletal muscle and fat content and insufficient fat intake were more pronounced (P .lt;0.001).
Immune globulin A and serum D-Lactic acid increased significantly in patients with HBV-ACLF.
IL-10 may be a potential predictive indicator of death in HBV-ACLF patients.
28-day survival of the nutritional support group was better than that of the non-nutritional support group (P s 0.016).
HBV-ACLF suffer from inadequate nutritional intake, higher nutritional risk, and impaired intestinal barrier function, the researchers concluded.
personalized and dynamic nutritional support were associated with a better prognostic prognosticity of 28-day mortality in patients with HBV-ACLF.
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