Worried about a long stay in the night sudden death? Taking care of the gut may be "spared"

Lack of sleep, circadian rhythm disorders can lead to intestinal barrier dysfunction and intestinal flora disorders, leading to the accumulation of reactive oxygen in the intestine, causing oxidative stress and cell damage, which is the key to the body's metabolic dysfunction and further induced sudden death, researchers from Harvard Medical School have found that long-term deaths are not the brain or heart, but the intestines, according to a study published in the international journal Celllong stays up long hours can cause premature death because of the accumulation of oxides in the intestinesAnd the researchers further demonstrated that by actively removing oxides from the animal's intestines, even if they stay up late for long periods of time, their longevity was no different from that of animals that maintained normal activitythe study has attracted a lot of attention from the academic communitySo why does the accumulation of oxides in the intestines cause sudden death? How does the study differ from previous perceptions of the causes of death from staying up late? Science and Technology Daily reporter interviewed domestic expertsstaying up late has become the new normal in life
, before the "China Sleep Quality Survey Report" released by the Sleep Respiratory Center of Chaoyang Hospital in Beijing shows that 16% of the 100,000 respondents covering all provinces of the country have less than six hours of sleep;in the eyes of experts, due to lifestyle changes, social competitive pressure and a series of factors, staying up late has become a new normal in lifeHowever, staying up late can do great harm to our health, an associate professor at China Pharmaceutical University, who has long been involved in intestinal probiotics and disease research, told reporters that staying up late can cause the intestines to produce large amounts of oxides, and reactive oxygen (ROS) accumulates in the intestinesDrLin Min of Changzhou Second People's Hospital, affiliated with Nanjing Medical University, explained that ROS is the general term of a class of active oxygenated compounds produced by the aerobic metabolism of organisms, including hydrogen peroxide, superoxygen ions, hydroxy free radicals and so on, said ROS destroys DNA and other components of the cell, destroying collagen and elastin based on skin elasticity, causing wrinkles and relaxation"ROS also stimulates pigment cells to produce a large amount of melanin, which in turn produces macula, butterfly spots, etc.; ROS also destroys the cell membrane, so that cells can not absorb nutrients from the outside, which in turn leads to cell death, so that tissue organs aging and even inducecardiovascular diseases, neurological diseases and tumors and more than 200 kinds of diseases." the dynamic balance of ROS production and digestion in a variety of ways Recent studies have revealed that ROS's participation in the normal physiological processes of cells is closely related to cell proliferation, differentiation and apoptosis "Lack of sleep, circadian rhythm disorders can lead to intestinal barrier dysfunction and intestinal flora disorders, leading to the accumulation of ROS in the intestine (especially the small intestine), which can lead to oxidative stress and cell damage, which is the key to metabolic dysfunction and further induced sudden death." Lin Min said a key role in the gut flora
experts say that sleep is the basis of human and other animal life activities, and that scientists have long studied sleep in an attempt to learn more about the mysteries of sleep, but there are still many secrets of sleep that cannot be untangled It is well known that if people do not get enough sleep, there are a number of serious consequences, including chronic sleep disorders, heart disease, type 2 diabetes
, cancer, depression and other diseases reporters learned that as early as 1983, there are American scholars through the study of rats found that long-term sleep deprivation can cause animal death Scientists then explored for decades, but never found the exact cause of the animal's death without sleeping " In recent years, with the development of microbiome and intestinal macrogenomics, scientists have found that the gut is involved in the development and development of a variety of human diseases, as well as that the gut can influence brain activity, even through the brain's intestinal axis interaction with the brain Lin Min explained that the brain and intestine strains are a system in the body that is made up of the brain and intestines The brain and intestines communicate with each other in the form of hormones and nerve messages, which together regulate a person's emotional response, metabolism, immune system, brain development and health sleep is an important physiological process regulated by the brain, and researchers have found that the gut, especially the gut flora, may be a key regulator of sleep mechanisms Lin Min introduced that the intestines participate in the body's various physiological and pathological processes, but also through nerves, endocrine, immunity and metabolism, and sleep awakening mechanism regulation Most studies have concluded that the regulation of sleep by intestinal flora is achieved through the combined function of many pathways in the intestinal axis of the brain Professor Chen Yongquan, dean of Wuxi School of Medicine at Jiangnan University in , said: "Previous studies have suggested that sudden death from late nighttime is associated with cardiovascular disease, such as sudden accidents in people who have some cardiovascular disease after staying up late But recently it has been found that some young people who die of sudden death do not have cardiovascular disease Therefore, the above-mentioned study by Harvard Medical School subverts the traditional understanding of the causes of sudden death "
antioxidants can mitigate negative effects
previous studies have shown that prolonged sleep suppression inevitably leads to premature death in animals, and most researchers have focused on research on the brain, which is the main organ that controls sleep, in order to find the mechanism of sleep deprivation death However, none of the researchers found useful clues in the study of the brain In the Harvard Medical School study, researchers chose fruit flies as subjects to find out why animals die without sleeping, said Lin Min, of the This is because the genes of fruit flies are very similar to those in humans, and their short life cycle is also suitable for observation found that persistent sleep deprivation in animals in the gut will accumulate ROS, which in the lead causes premature death in animals, then, artificial removal or neutralization of these oxides, can prolong the life of animals? researchers at Harvard Medical School found dozens of antioxidants that neutralize ROS and supplemented them with fruit flies, and found that sleep-deprived fruit flies had a normal or near-normal life span for fruit flies, while normal fruit flies replenished these substances without any change in life life , these antioxidants can extend the life of sleep-deprived fruit flies without other effects The researchers also promoted the expression of antioxidant enzymes in the gut or brain of fruit flies through genetic regulation, and found that intestinal antioxidant enzyme overexpression effectively prolongs the life of fruit flies, while the brain's antioxidant enzyme overexpression has no significant effect , said this not only further evidence that ROS accumulation in the gut plays a central role in sleep deprivation-induced deaths, but also suggests that eating antioxidant foods may help improve the health problems associated with lack of sleep " by neutralizing oxides, reducing oxidative stress in the intestines can offset the harm caused by lack of sleep, prolonging the life of insomniac animals, mainly through antioxidant supplementation It is worth mentioning that the existing research shows that many probiotics have antioxidant activity The study of the pathways and mechanisms of sleep regulation in depth provides a new way of thinking for the treatment of sleep disorders, he said but experts have suggested that while these studies have revealed how sleep disorders and gut flora can interact, researchers have not been able to figure out why lack of sleep causes ROS build-up in the gut and why it is so "fatal." So far, since studies on the relationship between the intestine and sleep disorders are still in their infancy, the specific mechanisms of how sleep disorders affect intestinal changes remain in animal experiments, and there is a lack of large-scale clinical studies on insomnia and intestinal problems, more in-depth research on the brain and intestinal axis may be needed in the future Yu Xiao Source: