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Protein is the material basis of all life and the most important carrier for organisms to perform their functions
From the analysis of the chemical nature, protein is a biological macromolecule formed by the carbon-nitrogen bond-forming reaction of amine-based units
Figure 1 Thecurrent mainstream peptide splicing method leaves a "scar" at the connection site (gray amino acid in the figure)
The team of researcher Wu Bian from the Institute of Microbiology, Chinese Academy of Sciences has long been engaged in the analysis and design reconstruction of the mechanism of microbial carbon and nitrogen bond-forming enzymes based on calculations
The PALME platform consists of an upstream activation module and a downstream connection module
Figure 2PALME platform with multiple inputs and outputs
To demonstrate the capabilities of the PALME platform, the team synthesized a series of important pharmaceutical peptides and unnatural proteins
Figure 3 Fully synthetic case: (top) Exenatide, a hypoglycemic drug; (bottom) cyclic SMAP antimicrobial peptide
Figure 4 Semi-synthetic case: (left) tautomerase; (right) acetylated heat shock protein mHSP10
In recent years, artificial intelligence technology has had a disruptive impact on the field of protein structure prediction and functional design
The senior engineer Li Ruifeng of the Institute of Microbiology of the Chinese Academy of Sciences, Zhu Tong, a doctoral student, and Dr.
Link to the paper: https://doi.
