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Recently, the research group of Professor Xiao Zeyu from the School of Basic Medicine published an article entitled Molecular Regulation of Polymeric Raman Probes for Ultrasensitive Microtumor Diagnosis and Noninvasive Microvessle Imaging in Small, a well-known journal in the field of nanomedicine
Raman imaging is an optical imaging technique based on scattering spectra generated by molecular vibrations
Organic polymers have good biocompatibility and have been widely used as fluorescent imaging probes for in vivo imaging
The probe overcomes the bottleneck that traditional organic polymer materials are difficult to generate high-sensitivity Raman signals due to fluorescence interference, realizes in vivo imaging of micrometastatic tumors in mouse colon cancer models, and achieves a spatial resolution comparable to that of SERS probes ; and achieved non-invasive microvascular imaging (Figure 1)
Assistant researcher Cui Kai, doctoral student Zhang Yongming, and doctoral student Chen Gaoxian of the School of Basic Medicine are the co-first authors of the paper