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    Home > Biochemistry News > Biotechnology News > Xue Yi's research group from the School of Life Sciences has made progress in rationally designing RNA transient structures

    Xue Yi's research group from the School of Life Sciences has made progress in rationally designing RNA transient structures

    • Last Update: 2022-04-21
    • Source: Internet
    • Author: User
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    In addition to the high-abundance ground state conformation (Ground States) with lower free energy, RNA in solution often also has low-abundance excited state conformation (Excited States, also known as transient conformation) with high free energy


    In this study, the authors used the RNA secondary structure prediction tool MC-Fold, through a series of design strategies and screening conditions, to obtain four types of RNAs that autonomously switch secondary structures in different ways









    The research work was published online on March 21, 2022 in the journal Nature Communications, titled "Rational Design of Hairpin RNA Excited States Reveals" (Rational Design of Hairpin RNA Excited States Reveals) Multi-step Transitions), the original link is https:// style="font-size: 18px;">



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