Yang Yizen: Big data empowers research in the field of non-coding RNA.

Why are the genes that express proteins so small in the genome? Why is there so much "junk DNA" in the genome? "That's because there are a lot of regions in the genome that are like 'dark matter' in the universe, and they actually have important functions and functions, but we've got very limited understanding of these regions right now.
through the analysis of a large amount of histological data, we have some understanding of some non-coding small RNAs, really small, large roles.
" first met, Yang Yi, a researcher at the Agricultural Biotechnology Research Center, gave an enthusiastic introduction to his research in the field of non-coding RNA.
genomic "dark matter" was a PhD student at the University of Virginia in the United States, Yang began to be interested in these "dark matter" through high-throughput sequencing methods to identify and understand the function of these non-coding areas.
" At that time in the field of plants there was no ready-made method, we began to learn from the animal's research methods, found a lot of differences, so we began to study the characteristics of this kind of plant in the non-coding small RNA, through more than two years of research, we captured the characteristics of these small RNA, developed their own research methods and the preparation of relevant analytical procedures.
now this approach is basically a universal method in the world, and there are nearly 50 plants that use our method to identify small RNAs.
," Yang said.
"We have recently made important improvements to the old methodology to make it more accurate, efficient, and faster.
" Yang said that the method has now been published in the field of biological information authoritative journal. the analysis of the function of the genome non-coding region in
is also a hot research topic in the world, and more and more research shows that these regions have important functions in terms of plant growth and development and response to the outside environment.
" can be said to be everywhere, although it is 'dark matter', the function is both 'mountain' and 'dew', very important.
" it was clear that Yang had a great passion for his research.
he believes that this direction will have important applications in the future.
", such as the RNAi drugs mentioned in Science's top 10 scientific developments in 2018, we can apply relevant research and methods to crop improvement, insect resistance and other fields.
" in the summer of 2017, Yang yily quit his job abroad and returned to work with his family.
"I hope to contribute to the construction of the motherland."
" talk can feel his strong patriotic feelings and the bone of love for agriculture, "I undergraduate is in China's agricultural university, 'to solve the difficult people's livelihood' school training has been deeply imprinted in their own minds."
"Putting big data on the wings of big data for breeders" breeding industry is the core of agriculture, our breeding methods need to be in line with the times, the latest research results and technology need to be integrated.
" Yang said that the country has been strongly aware of this, but also to this field has given a lot of support.
he admits that one of the motivations for his return is to apply his research experience in the field of breeding to domestic breeding.
2018, Mr. Yang was hired as a special expert in Beijing for his outstanding work in the agricultural sector.
", genomics has made great progress in the past ten years, and the field of crop research has accumulated a wealth of multi-group data, together with years of accumulated environmental data, metatype data, the data together, for breeding prediction and decision-making, has become the current international large seed companies very important method.
we must catch up in this area and hopefully be the frontrunner shorter in a relatively short period of time.
" his eyes were filled with hope.
chatted with Yang, unwittingly infected by his self-confidence and enthusiasm, but also by his agricultural complex moved.
growing up in the loess plateau, he always said, home to the land has a strong earth fragrance, China's agricultural development in the future can be expected, great.
related information: the main regulatory path of plant seed size plant seed size is an important yield characteristic, seed size regulation is also an important developmental biology problem.
therefore, the molecular mechanism of seed size regulation can provide theoretical basis and genetic resources for high-yield breeding of crops.
in recent years, the regulation mechanism of plant seed size has made rapid progress, and has become a hot spot and frontier in plant field research.
Li Yunhai Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has long been devoted to the mechanism of plant seed size regulation, has separated a series of key factors of seed size regulation in rice and amoeba, discovered several seed size regulation pathways, revealed the important mechanism of plant seed size regulation, and was invited to write a review of plant seed size regulation.
Li Yunhai Research Group has been invited to publish a review of the study on plant seed size in the journal Annual Review of Plant Sphanyin in the journal Of Annual Review of Planty (DOI: 10.1146/annurev-arplant-050718-095851) in the journal Annual Review of Plant.
the review article discusses in depth the synergistic regulation of seed size of signals from parent and congenial tissues, systematically combs the factors involved in seed size regulation, such as ubiquitin-protease pathway, MAPK signaling pathway, G protein signal, hormone and IKU pathway, and the interaction between them, and analyzes the existing problems in seed size research, possible solutions and future research directions.
this paper is not only of guiding significance to scientists engaged in plant seed size regulation, but also for the rational use of seed size genes for molecular design and high-yield breeding.
the work was supported by the Ministry of Science and Technology, the Ministry of Agriculture, the National Natural Science Foundation of China and the Chinese Academy of Sciences.
Li Yunhai Research Group, Dr. Li Na and Xu Ran, co-authors of the paper, and Li Yunhai as the communication author.
Source: Science Daily.