Yeast β glucosaccharose is intended to expand its use in infant and young children's foods

October


, the National Food Safety Risk Assessment Center on yeast β
-
glucosaccharides, as a nutritional enhancer to expand the scope of use of the public for comments., it is understood that the scope of expansion of the use of infant formula, infant auxiliary food, special medical use formula. The applicant for wider use is Angie's Yeast.Table
1
Yeast β
-
Glucosin Declaration Expanded Use β
-
Glucosamine Main Structure β
-
Glucosacin
D-
Glucose Monomer Borrowed by Glycoside Key The main chemical structure of polysaccharides formed by the connection is β
-1,3
glucosaccharides and β
-1,6
glucosaccharides, the former of which has anti-tumor activity, which can greatly improve the body's natural immunity, in addition, as a probiotic can also regulate the structure of the gut bacteri.β
-
glucosaccharides are widely found in a variety of fungi and plants, mainly from fresh foods such as beer yeast, oats, edible bacteria and so on. Among them, yeast β
-
glucosaccharide is a polysaccharide with immune-enhancing activity present in the walls of yeast cells, refined by yeast cells after self-dissolving, enzymatic, purification, molecular weight of about
10 00KD
, mainly to β
-1,3-D-
glucosamine as the main chain, the structure is different from the general sugar line molecular structure, for a unique triple super-micro-helix structure. This particular ultra-micro-helix molecular structure is the most immune active and easily absorbed by the human body, so in animal experiments show non-specific immune enhancement.the biological activity β
of
yeast β
-
glucosaccharides, etc., makes it have the physiological activity of lowering cholesterol and blood lipids, increasing the body's immunity and so on. Numerous studies have shown that the immunomodulation mechanism of yeast β
-
glucosaccharides is specific to the immune cells of animals and humans (including single cells, macrophages, neutral granulocytes and natural killer cells) and produces immune activity to the body by stimulating lymphocytes in animals and macrophages in activated animals. Therefore, yeast β
-
glucosaccharose has a variety of immune functions.1.
Antrogenic, anti-tumor The main goal of currently studying anti-cancer function is to strengthen the activity of macrophages in human tissue, which is being used by glucosaccharides.
Cheung NK
and other immunodeficiency allogeneic transplant tumor models to study β
-(1
→
3)-
glucosaccharides, and tested the relationship between its anti-tumor effect and physical and chemical properties, the study found that oral β
-
glucosamine significantly increased the anti-tumor monoclonal antibody
(mAb)
in mice established anti-tumor effect.2.
Antioxidant, anti-radiation β
-
glucosaccharine effectively removes free fundamentals from the body and protects macrophages from free fundamentals during and after exposure to radiation, allowing them to continue to function normally. Cell culture experiments have shown that methyl β
-
glucosaccharine inhibits the consumption of antioxidant molecules under ultraviolet radiation and promotes the growth of ketoatin, thus protecting skin cells.
such as pathchenML
have shown that water-soluble glucosaccharides enhance rapid recovery from cobalt
-60
-induced radiation. Treating radiant mice with β
-
glucosaccharoids can enhance the ability of mice to recover, and can improve bone marrow vitality, increase the number of white blood cells, and enhance the number of spleen cells.3.
Promote wound healing Because macrophage activity plays an important role in surgery and wound healing, β
-
glucosaccharides have the ability to participate in the body's natural defenses and accelerate skin wound healing.
Waisun
and other studies have found that
20
to
100 mg/ml
yeast glucosin smeared on the legs of animals, can significantly accelerate the healing of their wounds, the application of
0.1
to
0.2
mg/kg weight of soluble glucosamine, can reduce the infection rate after abdominal surgery.4.
Lowering cholesterol and lipids β
-
the special structure of glucosamine can promote lipoprotein, fatty acid release, so that the lipids of large molecules in the blood break down into small molecules, so that excessive blood lipids caused by serum turbidity has a clarifying effect, can significantly reduce blood cholesterol.
Nicolosi
and others studied
15,
obese men with high cholesterol who maintained the same body weight and significantly reduced total cholesterol levels in the blood by week
7

8
%, on the basis of week
7
, the
8
week reduced by
6
%, it can be seen that yeast glucosaccharine can significantly reduce the cholesterol content in the plasma.the effect of adding yeast β
-
glucosaccharine in food compared to(
1
) infant formula - milk powderafter adding a certain amount of yeast β
-
glucosamine, testing the yeast β
-
glucosaccharose content, as follows: table table
2-1
milk
Add yeast β
-
glucosaccharide before and after the use of the effect comparison table compared with no added milk powder, add yeast β
-
glucosaccharide milk powder content of
50mg/100g
, yeast β
-
glucosaccharide by activating the activity of macrophages in the body, thereby enhancing the activity of the body's immune system, can enhance the activity of infants and young children. (
2
) infant auxiliary food - rice flour add a certain amount of yeast β
-
glucosaccharine, test the yeast β
-
glucosaccharin content in rice flour, table: table
2-2
rice flour added yeast β
-

Compared with the non-added milk powder , the content of added yeast β
-
glucosaccharide milk powder reached
50mg/100g
, and the yeast β
-
glucosaccharides enhanced the activity of macrophages in the body by activating the activity of macrophages in the body, thus enhancing the immune system activity of infants and young children. (
3
) special medical use formula - infant formula added a certain amount of yeast β
-
glucosaccharies, test the yeast in infant formula β
-
glucosaccharine content, as follows table: Table
2-3
Add yeast to infant formula β
-
Glucosaccharies before and after use effect comparison table
added yeast β
-
glucosaccharine milk powder content of
21mg/100g
, yeast compared to infant formula without special medical use β
-
glucosaccharides enhance the activity of the body's immune system by activating the activity of macrophages in the body, adding yeast to the formula of premature
/
low birth weight β
-
glucosaccharose can enhance the immunity of infants and young children. (above from the official website of the National Food Safety Risk Assessment Center
2016-10-11
) According to Shitiqiao Media, because yeast β
-
glucosaccharides have enhanced immunity, anti-infection, radiation and other effects, can be used as functional food and dietary supplements raw materials. China's Ministry of Health
2010
No.
9
, approved yeast β
-
glucosaccharide as a new food raw material, in addition to yeast β
-
glucosaccharide also has a fat-like taste, can be used as a low-calorie food additives, salad dressings, cheese similars and other frozen desserts as fat substitutes. The ministry
approved yeast β
-
glucosaccharides as a new variety of food additives in Proclamation no.
6
of 2012
, with a functional category of nutritional enhancers.
October

, 2016
10
11
, the National Food Safety Risk Assessment Center on yeast β
-
glucosaccharies to expand the scope of application, it seems that the promotion of regulations will make yeast β
-
glucosaccharose in the field of food has been more and more widely used. table
3
regulations on yeast β
-
glucosaccharies