Yeast may cause enteritis

, a new study published in the journal
suggests that a yeast in the gut may exacerbate cronin disease, while blocking the fungus can reduce symptoms in some inflammatory enteropaths.
more than a million Americans currently suffer from inflammatory bowel disease, and while many patients can control symptoms with anti-inflammatory drugs, they are not effectively curable. Although symboxic microorganisms are known to play an important role in host health, and there are many microbiomes such as fungi, ancient bacteria and viruses, most studies focus only on bacteria. Previous studies have found yeast brewing bacteria in patients with Clun disease, and nearly 70% of patients have an immune response to yeast, suggesting that the fungus may be related to the severity of the disease, but little attention has been paid to its specific relationship with inflammatory enteropathy.
To find out, Tyson Chiaro of the Department of Pathology at the University of Utah School of Medicine and colleagues found that the Saccharomyces cerevisiae strain increased intestinal damage in mouse models with colitis. Moreover, experimental results show that the yeast causes an increase in uric acid levels in the intestines of rodents. They then gave the mice animal allopurinol, which reduces uric acid production, in their intestines and found that their intestinal symptoms had been reversed.
researchers examined serum taken from 168 healthy volunteers to determine whether yeast could have a similar effect in the human body; they observed a positive correlation between uric acid concentrations and brewing yeast circulating antibodies. The team said detecting uric acid and immune response to yeast in patients with cronin disease could help with targeted interventional therapy studies. (Source: Science Network Zhang Zhang)