Yin Yuxin's team discovered a new mechanism of long-distance communication between organs: lung tissue extracellular vesicles regulate bone marrow..

On May 20, 2022, Yin Yuxin's team from Life Center and Peking University School of Basic Medicine published a paper entitled "Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation" in the journal 【Journal of Extracellular Vesicles, IF=26】.

EVs have been recognized in recent years as biomarkers for many diseases and as carriers of long-distance communication between cells

The lung is an important respiratory hematopoietic organ

To solve the above problems, Yin Yuxin's team successfully established an efficient method to collect high-quality EVs from human and mouse normal lung tissues

Further studies confirmed the presence of dsDNA both inside and outside the membranes of lung EVs

In conclusion, this study established a high-quality isolation and purification system for lung tissue EVs, which can accurately delineate their molecular composition and study their distal regulatory functions in vivo

Liu Bowen, a 2017 direct doctoral student at Peking University School of Basic Medicine, and Jin Yuan, a postdoctoral fellow at Peking University School of Basic Medicine are the co-first authors of the paper, and Professor Yin Yuxin from the Life Center and the Institute of Systems Biomedicine, Peking University School of Basic Medicine is the corresponding author

Original link: https://doi.