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    Home > Medical News > Latest Medical News > Ying uses human stem cells to reconstruct the complete thymus

    Ying uses human stem cells to reconstruct the complete thymus

    • Last Update: 2020-12-22
    • Source: Internet
    • Author: User
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    According to a proof-of-concept study published in the journal Nature Communications, scientists at the Francis Crick Institute in the UK and University College London used human stem cells and bioengineering stents to reconstruct the thymus, an important organ of the human immune system, an important step towards building an artificial thymus that can be transplanted.
    thymus is a chest organ in which T lymphocytes, which play a vital role in the immune system, mature. If the thymus does not work properly or does not form during fetal development in the womb, it can lead to diseases such as the body's inability to fight infectious diseases or severe immunodeficiency diseases of cancer cells, or autoimmune diseases in which the immune system mistakenly attacks the patient's healthy tissues.
    new study, scientists used stem cells from patients' organs that had to be removed during surgery to reconstruct the thymus. When transplanted into mice, the bioengineered thymus supports the development of mature functional human T lymphocytes. This is the first time scientists have successfully reconstructed a complete human thymus.
    to reconstruct the organ, the researchers collected the thymus from patients and cultured donated tissue thymus epithyroid cells and thymus interstitial cells into billions of cells in the lab. To obtain a structural stent for the thymus to be reassembled with cultured thymus cells, the researchers developed a new way to remove all cells from the thymus in mice and retain only the structural stent.
    researchers injected organ stents with up to 6 million laboratory-cultured human thymus epithal cells and interstitrinal cells. The cells grow on the stent, and after only five days, the organ has developed to a stage similar to that of a 9-week-old fetus. Finally, the researchers implanted these thymuses into mice. They found that more than 75 percent of the thymus supports the development of human lymphocytes.
    say thymus transplants often lead the immune system to reject transplants. The thymus, which grows by transplanting cells extracted from the thymus of an organ donor, may be able to overcome this problem and eliminate the need for immunosuppressants for the rest of the patient's life.
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