Yinos biotechnology makes the party emblem shine on the post of protecting the safety of new drugs

[enterprise news of China Pharmaceutical network] the safety assessment center has grown up in the market-oriented development environment In order to better adapt to the market and the cruel competition environment, the joint-stock reform has been carried out In 2010, the Shanghai Yinuosi Biotechnology Co., Ltd with the nature of mixed ownership was established, running in parallel with the two brands of safety assessment center (Party members visit the second branch of yinos Biotechnology Co., Ltd of Navigation Museum for drawing) Since April this year, Shanghai Municipal Economic and information work party committee has extensively carried out "five good branches grand tour and one hundred strong branches grand exhibition" activities in the system, selected and produced 104 "Party branch construction demonstration points" from more than 3700 party branches in the system, and formed a number of replicable and generalizable grass-roots party construction achievements through various tour and exhibition activities From now on, the Party committee of Shanghai Municipal Economic and information technology work together with Shanghai channel of people's network to launch the "top 100 branches" The series reports of "model power" make more grass-roots party branches have goals and models, set a benchmark and set a good example for further improving the standardization level of grass-roots Party branch construction, and play a greater exemplary role for Shanghai to continue to "be a good pacesetter" and achieve "four new actions" "Qiu Bo, there was a decrease in activity in the middle dose rats in my experiment." how long did it appear after administration? How long did it last? "When I walked into the gate of Shanghai new drug safety evaluation research center, I often heard such a dialogue It is often said that "it's the third poison of drugs" Before the clinical application of new drugs for the treatment of human diseases, it's necessary to conduct safety experiments on animals, measure whether they are toxic, and what is their safe range and safe dose In this process, safety evaluation is required in every link of new drug research and development This work is the safety evaluation center's full program toxicology Service The national Shanghai new drug safety evaluation and research center is the center of China Pharmaceutical Group and the end key link of the technological innovation chain of China Pharmaceutical Industry Research Institute As the "national team" of new drug safety assessment in China, it is one of the outsourcing units of new drug research and development that has passed the GLP standard laboratory standard certification in China It has been more than ten years since its initial settlement in Zhangjiang After continuous cultivation and experience, the safety assessment center now has reached a series of management processes and specifications from planning, experiment, supervision, record to report issuance Jigao standard "The safety assessment center has gradually grown up in the market-oriented development environment In order to better adapt to the market and adapt to the cruel competition environment, we boldly carried out the joint-stock reform In 2010, we established the Shanghai Yinuosi Biotechnology Co., Ltd with the nature of mixed ownership, which runs in parallel with the two brands of safety assessment center From the development process of these years, we have not only trained the team, accumulated public praise and experience, but also achieved sound development in economic benefits and enterprise scale " "In this process of development, the role of Party members in the second party branch of eNOS is particularly prominent," Chang Yan, general manager and Secretary of the general Party branch of eNOS (Safety Assessment Center), told reporters The second party branch of innos (Safety Assessment Center) covers most departments in the front line of scientific research There are 26 party members, including 8 doctors and 13 masters, with an average age of 30 years "It can be said that this is not only a young business backbone team, but also a mature, stable and capable Party member pioneer team From them, it embodies the enterprise mission of" quality is vital to life, safety assessment is more important than Mount Tai ", and strives to implement the call of" being a good leader in reform and opening up, and a pioneer in innovation and development " Song Zheng, Secretary of the second party branch and a doctoral Party member, told reporters "It's not easy to say no! It's a great event related to life safety." the safety evaluation of new drugs is an important link of preclinical research of new drugs, often related to the success or failure of drug research and development On the one hand, some drugs have to stop development due to unexpected toxic reactions, on the other hand, good safety evaluation design can also make the drug "come back from the dead" Song Zheng gave several examples to reporters, such as a new blood lipid lowering drug, which still had obvious testicular toxicity at close to the effective dose, and had to stop the development because there was not enough safety window; another biological similar drug, which had to give up because of the toxicity reaction not observed by the reference drug (which has been listed abroad) Often at this time, a large amount of the enterprise's early investment will be wasted, let alone the cost of time and energy "At this time, the party members of the branch always take the initiative to think of ways and ways to prevent any possible success from sneaking away under their noses, and do not easily convey the failure information to the entrusted customers." "Don't say no easily" has become the creed that party members of the second branch always adhere to in their work Once, the center received a new target small molecule anti-tumor targeted drug toxicity evaluation According to the client's experimental entrustment, Beagle dogs were selected for the test Soon, it was found that serious toxic reactions would occur under extremely low doses At one time, people thought that the new drug "has little future" Li Hua, a careful Party member doctor, found that the appropriate species for in vitro metabolism research was primates, so he immediately decided to use monkeys for toxicity evaluation, and it was found that the drug was very well tolerated in monkeys, thus successfully completing the follow-up work At present, the drug has entered phase II clinical "A good, comprehensive and rigorous safety evaluation design is to" guarantee and escort "the entry of new drugs into clinical trials." Said Dr Li Hua modestly and firmly "In the face of the lives of these lovely animals, we have no words..." An animal monument stands on the lawn in front of the safety assessment center The inscription reads: "in the face of the lives of these lovely animals, we have no words..." This special corner makes the camphors around it solemn Every year on the animal memorial day, all the staff will stop their work and gather here to observe the silence of the experimental animals who died for the cause of human health At first, the ceremony activity with the characteristics of Anping was initiated by the second branch For the party members of the second branch, they face these experimental animals every day Their care and respect is not only a kind of humanistic care, but also a kind of love and responsibility As an organization applying for AAALAC (International, non-profit animal management assessment and certification organization) qualification certification in Shanghai, the safety assessment center has passed the certification for the third time this year From the initial exploratory passive acceptance to the current breakthrough active participation, song Zheng, Secretary of the Party branch of the second branch, felt a lot, "since the center accepted AAALAC certification, we have gradually got a clear understanding and grasp of the specific process, especially after we became a volunteer prosecutor later, when we went to other units for inspection, we will also reflect on whether our units have similar problems, Further clarify the rules in communication and discussion Taking care of the physical and mental health of animals is the key to ensure the quality of experiments, and it is also something we should strengthen in the future Not only do we have to do this ourselves, but last year we also launched a training course to let more domestic peers know and exchange, which has been affirmed and welcomed by everyone " "We are all part-time volunteers to promote animal welfare related work While doing our job well, most of us ask for annual leave to go out for inspection The rules we have learned are relatively new We will follow up the time and do animal welfare related work according to high standards The concept we advocate is' better animal welfare, better science '." Today, yinuos (Safety Assessment Center) is a member of AAALAC Dr Song Zheng and Dr pan Xueying of the second branch are both voluntary prosecutors of AAALAC At the same time, song Zheng also serves as the chairman of IACUC "Walk ahead, do first, set an example" in the "two studies and one work" learning and education, the second branch puts forward the requirements of "walk ahead, do first, set an example" to the party members In order to coordinate the work of all departments, the learning time of the branch is always in the lunch break, but each party member has no complaints and actively cooperates The training contents include not only business practice, but also education of Party members and incorruptible government In combination with the characteristics of young people, the branch also carried out its learning and education activities in a vivid way by integrating new media teaching methods such as video teaching, film teaching and mobile micro party class At the same time, the branch also actively builds a platform for the growth of Party members Dr Tang Naping was sent to Pfizer's safety and pharmacology department for one and a half months of training "At that time, these advanced methods were not easy to learn in China, so I felt like a treasure It was not easy to study in the daytime and review in the evening, and I thought about how to combine with the work of the center It was not easy to come out, so I must bring them back as much as possible." After returning to the center, he did not fail to live up to expectations He revised the SOP related to the central safety pharmacology test of rats and established the FOB test method to ensure the sensitivity of the central safety pharmacology test method At the same time, the respiratory system safety pharmacology method and cardiovascular safety pharmacology test method were optimized, and the safety evaluation of a number of class 1 drugs was carried out by using the optimized method, which not only improved the overall level of the center in this field, but also was recognized by peers and enterprises at home and abroad Chang Yan, Secretary of the general Party branch, told reporters that eNOS has trained more than 3000 people every year, both externally and internally Especially in the internal training of the Department, Party members are always the main training backbones The "animal test manual" they take the lead in writing not only improves the quality and efficiency of the staff, but also lays a solid foundation for the Department to complete a large amount of work every year "It is under the influence and Inspiration of the exemplary role of these party members that in the past three years, the second branch has new blood to join in every year These new party members not only have outstanding performance in business work, but also become new benchmarks and leaders in their posts." Chang Yan introduced "The second branch is a united and warm family" There are four party members or trade union members in the second branch In addition to their busy work, Party members and comrades actively and enthusiastically organize various activities, such as book corner, interesting sports meeting, parent-child activities, etc., to send warmth in winter and cool in summer "The second branch is a big family of unity and warmth." the party members said so about the Party branch in their hearts In recent years, the number of unmarried and non local employees in the center has increased gradually Party members will take the initiative to take advantage of the weekend to go to the dormitory to have a look, talk with them, understand their needs and difficulties Sometimes, everyone will cook a meal together to warm the hearts of these non local students and "empty nest youth" "In the face of difficulties, Party members always take the initiative to give care and warmth to each other In the face of honor, Party members always take the initiative to step up the ladder." Li Hua, director of toxicology, commented on the party members of the second branch Because of such a team,