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    Home > Biochemistry News > Biotechnology News > Young people got Parkinson's disease after contracting the new crown!

    Young people got Parkinson's disease after contracting the new crown!

    • Last Update: 2021-12-28
    • Source: Internet
    • Author: User
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    The scary thing about the new coronavirus is that it not only causes respiratory symptoms, but also affects other tissues and organs
    .
    Recently, some studies have found that some young people have symptoms of Parkinson's disease after being infected with the new crown! And a recent paper shows that this may not be accidental.
    .
    .

    In the journal ACS Chemical Neuroscience under the American Chemical Society, researchers found that the N protein of the new coronavirus can interact with α-synuclein to accelerate the formation of amyloid deposits
    .
    And α-synuclein is one of the typical pathological proteins of Parkinson's disease

    .

    Cases of neurodegenerative disease caused by viral infection are not uncommon
    .
    During the influenza pandemic in 1918, it was discovered that the number of sleeping encephalitis cases increased during the same period, followed by many cases of Parkinson's disease after encephalitis

    .
    It’s just that people don’t know whether the immune response brought about by a virus infection affects the brain, or whether the virus can directly affect the brain

    .

    For neurodegenerative diseases such as Parkinson's disease, abnormal accumulation of certain proteins is a typical pathological feature
    .
    Once the accumulation begins, it will "spread" from one cell to another, thereby affecting brain function

    .
    Some previous studies have also shown that Alzheimer's disease has some associations with certain viral infections

    .

    Based on the symptoms of Parkinson's disease in some young people after contracting the new crown, the researchers decided to explore the relationship between the two diseases
    .
    Specifically, they used a fluorescent probe to label α-synuclein amyloid fibrils and explored the impact of the new coronavirus on the deposition rate

    .

    In the absence of the new coronavirus, the researchers found that it takes more than 240 hours for α-synuclein to accumulate to form fibrils
    .
    When the researchers added the spike protein (S protein) of the new coronavirus to the test tube, the deposition rate did not change

    .

    What's interesting is that when they added the N protein from the new coronavirus, the speed of deposition formation was greatly accelerated-it only takes less than 24 hours for α-synuclein to accumulate!

    ▲The effect of new crown S protein (left picture) and N protein (right picture) on the deposition rate of α-synuclein
    .
    The black picture on the left is the α-synuclein control, red, orange, and blue represent S protein with 0.
    1 μM, 0.
    5 μM, and 1.
    0 μM added respectively; the black on the right is the α-synuclein control, red, orange, Green and blue represent N protein with 0.
    1 μM, 0.
    5 μM, 0.
    8 μM and 1.
    0 μM added respectively (picture source: reference [1])

    Further research found that the N protein and α-synuclein of the new coronavirus can be directly combined with each other through different charges! In the model, each N protein can bind at least 3-4 different α-synuclein
    .

    In order to confirm the results observed in the test tube, the researchers used a Parkinson's disease cell model for analysis
    .
    They did two sets of experiments.
    One group only injected α-synuclein into the cells, and the other group injected N protein close to the body's concentration

    .
    The results showed that the latter caused cell death twice as much as the former!

    What is even more exaggerated is that after the simultaneous injection of N protein, the distribution of many α-synuclein proteins has changed, and the structure has also been lengthened, which makes people doubt whether this is amyloid deposition (not yet confirmed)
    .

    ▲This study found that the new crown N protein can bind to the typical pathological protein of Parkinson’s disease α-synuclein (picture source: reference [2]; Adapted from ACS Chemical Neuroscience 2021, DOI: 10.
    1021/acschemneuro.
    1c00666)

    The authors pointed out that a major symptom of the new crown we know is that people lose their sense of smell and taste, and the loss of smell and taste is precisely the early symptom of Parkinson's disease
    .
    At present, we are not sure whether the phenomenon observed in the cell model can be repeated in the neurons of the human brain

    .
    But if so, it can explain many phenomena and link the new crown infection to Parkinson's disease

    .

    Reference materials:

    [1] Slav A.
    Semerdzhiev et al.
    , (2021), Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation, ACS Chem.
    Neurosci.
    DOI: https://doi.
    org/10.
    1021/ acschemneuro.
    1c00666

    [2] SARS-CoV-2 protein interacts with Parkinson's protein, promotes amyloid formation, Retrieved December 14, 2021, from https://

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