echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Endocrine System > Your baby's birth weight is linked to lifetime diabetes risk -- the lower your body weight, the sooner you may develop type 2 diabetes

    Your baby's birth weight is linked to lifetime diabetes risk -- the lower your body weight, the sooner you may develop type 2 diabetes

    • Last Update: 2022-06-13
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    Edited by Yimaitong, please do not reprint without permission


    The development of diabetes is influenced by both genetic and environmental factors.
    Early life conditions are associated with diabetes risk in adulthood.
    Birth weight is an important marker of early life development and has been linked to impaired glucose tolerance, insulin resistance, and coronary heart disease.
    More scholars believe that birth weight may affect lifelong health


    Lower birth weight may be associated with lower age at onset of type 2 diabetes and BMI at diagnosis, according to a study published in the journal Diabetes Medicine

    The research was led by Professor Ewan R.
    Pearson and colleagues at the University of Dundee School of Medicine in the United Kingdom


    The researchers collected birth data from a population born in Dundee, Scotland, between 1952 and 1966, and compared it with a population with diabetes diagnosed in the National Health Service (NHS) between 1995 and March 2017

    The study included 1509 patients with type 2 diabetes.
    After multiple regression analysis, each average loss of 1 kg in birth weight was associated with an earlier diagnosis of type 2 diabetes by 0.
    87 years (95%CI, 0.
    4), and the BMI at the time of diagnosis was also higher.
    Reduced by 1.
    49 kg/m^2


    1% of the patients progressed to require insulin therapy during a median follow-up of 5.
    39 years


    For each 1-year delay in age at diagnosis of type 2 diabetes, the risk of needing insulin therapy was reduced by 1.
    9% in women (HR=0.
    98; 95% CI, 0.
    99; P=0.
    038) and by 33% in men (HR=0.
    67; 95%) CI, 0.
    84; P < .
    001), while birth weight was not associated with the likelihood of needing insulin therapy


    The researchers believe that younger diabetic patients with low birth weight have lower BMI, and this association is mediated through reduced beta cell function, as lower BMI and higher HDL are markers of insulin sensitivity

    And this conjecture requires more research to explore the mechanisms behind these connections

    Large-scale Chinese study: Baby birth weight is related to lifetime diabetes risk.
    In 2019, a Chinese study published in the Journal of Diabetes showed that low birth weight (<2500g) or high birthweight (≥3500g) of babies was associated with adulthood.
    There is a significant correlation with the risk of developing diabetes


    This is a large cohort study in a Chinese population

    Overall, people with low (<2500g) or high birthweight (≥3500g) had a significantly increased risk of diabetes in adulthood compared with those with birthweights within the normal range (2500-3499g)

    Among them, the highest risk is the population with low birth weight and later overweight/obesity

    However, the results of the gender subgroup analysis showed that among the four male cohorts, the researchers observed a significant increase in diabetes risk only in the cohort with a birth weight of <2500g

    Therefore, there appears to be a "girl over boys" phenomenon between birth weight and diabetes risk


    In conclusion, the above studies suggest that, for diabetes prevention, attention should be paid to the birth weight of infants

    Developing good eating and exercise habits in your child, and keeping your weight within a healthy range, will greatly reduce your risk of diabetes

    References: [1] Paulina C, Donnelly LA, Pearson E R.
    The impact of birthweight on subsequent phenotype of type 2 diabetes in later life[J].
    Diabetic Medicine, 2022: e14792.
    [2] Chunyan HU, Yiming MU, Qin WAN, et al.
    Association between Birthweight and Diabetes: the Role of Body Mass Index and Life>
    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.