Yu Xuefeng, researcher team of Shenzhen Advanced Institute of Chinese Academy of Sciences successfully developed the near infrared two zone response drug controlled release system

Recently, Yu Xuefeng, research team of material interface research center of Shenzhen Institute of advanced technology, Chinese Academy of Sciences, has made new progress in the field of drug control and release in response to infrared region II Relevant work "inse nanosheets for efficient nir-ii-responsive drug release" was published in ACS Applied Materials & interfaces (DOI: 10.1021 / acsami 9b06170), an authoritative journal in the field of chemistry The first author of this paper is visiting graduate student Huang Chi, and researcher Yu Xuefeng and associate researcher Zhou Wenhua are corresponding authors Cancer, as an important cause of death, causes a huge burden to the family and life of patients Chemotherapy, as a traditional cancer treatment, can cause serious side effects and drug resistance due to frequent administration and non targeted treatment The stimulation responsive drug controlled release system can realize the precise control of drug release at tumor site under the stimulation of pH, biomolecule and light Near infrared two region (nir-ii, 1000-1350 nm) laser has been widely concerned because of its convenient operation and strong tissue penetration To solve this problem, Yu Xuefeng's research team developed a drug controlled release system with near nir-ii response based on inse nano tablets, which can control drug release remotely and accurately, kill tumor cells, and reveal its potential as a nano chemotherapy drug As a new type of two-dimensional material, inse nano sheet has attracted much attention due to its near-infrared response The band gap of inse nanoflakes can be controlled by changing the thickness of the nanoflakes, which has a wide spectrum absorption and may have the photothermal conversion property of nir-ii In addition, inse nano tablets have two-dimensional armchair or zigzag structure, showing a large specific surface area, which can be used for efficient drug loading The se atom in the inse nano tablet can provide the lone electron pair active site Through the electron pair - π interaction, the interaction between the inse nano tablet and the aromatic ring molecule of the drug is enhanced, and then the loading capacity of the tumor drug DOX is increased Therefore, it is of great significance to develop a nir-ii response cancer treatment platform based on inse nano tablets The research team found that in addition to the nir-ii response photothermal conversion efficiency, inse nano tablets also have a very high loading efficiency of adriamycin (DOX), as well as a very good biocompatibility Cancer cells ingest large amount of inse-dox complex by endocytosis Under the irradiation of nir-ii laser, inse nano tablets produce local overheating effect, realizing the controlled release of DOX, thus inhibiting the proliferation of cancer cells However, for normal cells, due to their weak uptake activity and metabolic rate, inse-dox complex intake is less, thus maintaining a high biocompatibility In-depth cell experiments show that inse-dox has a very good killing effect on tumor cells at low concentration This study not only shows the great prospect of inse-dox complex in the field of nano chemotherapy drug development, but also reveals the new direction of nano materials in the field of tumor treatment The research work was funded by NSFC, Guangdong Provincial Leading Talents Program, Shenzhen peacock project, Hong Kong research funding project and other projects.