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    Home > Medical News > Latest Medical News > Yuan Guoyong interprets the first new crown secondary infection: how it affects the vaccine

    Yuan Guoyong interprets the first new crown secondary infection: how it affects the vaccine

    • Last Update: 2020-12-03
    • Source: Internet
    • Author: User
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    August 24, Yuen Kwok-yung, chair professor in the Department of Microbiology at the Li Ka-shing School of Medicine at the Chinese Academy of Engineering at
    and
    University, and his team received a new study from Clinical Infectious Diseases, which will be published in the near future. The study revealed the case of
    a 33-year-old man who was second-degree infected with SARS-CoV-2, case
    No. 564, a
    resident who was diagnosed with neo-corona pneumonia at the end of March, recovered in mid-April, was discharged from hospital in August, travelled to the United Kingdom, Spain, returned to Hong Kong for routine screening at
    International Airport and tested positive again for SARS-CoV-2 on 15 August.
    what does this confirmed case of COVID-19, the world's first confirmed second-degree infection to date, mean? How does the team determine whether the patient's thinking on secondary infection, new coronary prevention and control needs to be re-considered, and whether the vaccine, which is still in clinical study, can bring hope? On August 25th, Yuan Guoyong gave a detailed reply in an interview with Yu News.
    Yuan Guoyong first mentioned that genome-wide analysis showed that the patient's first and second SARS-CoV-2 strains belonged to different branches/spectrums, and that there were 24 nucleotide differences between them, indicating that the second detected strain was completely different from the first detected strain. A number of clinical indicators after the patient's hospital isolation indicate that the second infection is a real acute infection.
    Notably, Yuan Guoyong stressed that previous studies have shown that antibody levels in new cases of coronary mild disease are low and can be lowered within a few months, "so it is not surprising that re-infection occurs after 4-5 months." "Another reality is that most of the new crown patients in this outbreak are mildly infected. In general, he argues, the more severe the symptoms and inflammation, the longer the immune response lasts.
    it's worth noting that there are voices that the results of this study are a blow to the new crown vaccine. But Yuan Guoyong stressed that, in fact, the patient quickly produced antibodies during the second infection and reduced the viral load. "As a result, minor COVID-19 patients may still need to be vaccinated for rehabilitation, and this group still needs to wear masks, observe hand hygiene and maintain social distance."
    Yuan Guoyong believes that two doses of vaccination will be the right way to obtain reliable immunization. "But how long is the immune response after a natural infection or vaccination?" This has yet to be further studied. "Here's a transcript of a question-and-answer session between a journalist and Professor Yuan Guoyong:There are many reasons why it's a secondary infection rather than the so-called "fuyang", a long-term detox.
    First and whole genome analysis showed that the first and second SARS-CoV-2 strains belonged to different branches/spectrums, with 24 nucleotide differences between them, indicating that the second detected strain was completely different from the first detected strain.
    In second, the patient's blood inflammatory markers increased (C-reactive protein), the viral load was relatively high and then gradually decreased, and on the fifth day of hospital isolation, the patient's serum went from no antibodies to the detection of SARS-CoV-2 antibodies, indicating that this was a real acute infection.
    142-day interval between the third, first and second infections. Previous studies have shown that most patients do not detect viral RNA a month after symptoms appear. There have been previous reports of prolonged detoxes for more than a month, but few. As far as I know, in one report, a pregnant woman was still infected for up to 104 days after her first positive test.
    fourth, the patient has recently been to Europe, where there have been new cases of coronary pneumonia since late July 2020. The viral genome obtained during the second infection is closely related to the systematic development of strains collected in Europe in July and August.patients are 33-year-old healthy individuals with no underlying diseases. His blood cell count, liver and kidney function is normal.the number of studies on immunization duration is still insufficient. But in general, the more severe the symptoms and inflammation, the longer the immune response lasts.two doses of vaccination is the right way to consolidate immunization. In fact, the patient quickly produced antibodies and reduced viral load during the second infection. But this case suggests that re-infection is indeed possible. As a result, minor COVID-19 patients may still need to be vaccinated for rehabilitation, and this group still needs to wear masks, observe hand hygiene, and maintain social distance.
    In addition, Yuan Guoyong
    listed eight key points worth noting in this outbreak:
    1, there are many mild diseases in this outbreak;
    2, overall, 50% of cases may be mild;
    3, previous reports show that the level of antibodies in mild cases is low, can be reduced to lower levels within a few months.
    4, so it is not surprising that re-infection occurs after 4-5 months;
    5, more research is needed to understand the likelihood of this happening;
    6, but patients produce antibodies and reduce viral load within 5 days of hospital isolation, suggesting that the immune system triggered by the first infection may respond quickly to remove the virus infection;
    7, two doses of vaccination is the right way to obtain reliable immunization.
    8, but how long is the immune response after natural infection or vaccination? This has yet to be further studied.
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