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On July 13, 2021, Professor Zhang Chuanmao's laboratory in the School of Life Sciences of Peking University published a research paper entitled " Sufu negatively regulates both initiations of centrosome duplication and DNA replication " in the Proceedings of the National Academy of Sciences ( PNAS ) .
The centrosome is composed of two vertical cylindrical centrioles and a peripheral matrix
In this work, the team found that cells that knock out Sufu undergo centrosome expansion (centrosome overreplication) and multipolar spindle formation, while restoring Sufu expression can inhibit centrosome overreplication and restore the normal number of centrosomes.
Schematic diagram of the molecular mechanism that Sufu negatively regulates centrosome replication and DNA replication initiation at the same time
The team further studied and found that the cells that knocked out Sufu had phenotypes such as increased nuclear volume, increased chromosome number, and abnormal cytokinesis
In summary, this work identified the Hedgehog signaling pathway related protein Sufu as an upstream regulatory protein that regulates centrosome replication and DNA replication initiation, and is a master switch, and initially revealed that Sufu protein regulates centrosome replication initiation.
Professor Zhang Chuanmao, School of Life Sciences, Peking University, is the corresponding author of this paper, 2014 PhD student Zhuang Tenghan is the first author of the paper, several other members of the laboratory such as Zhang Boyan and Song Yihong, and collaborators Cheng Yan from Nanjing Medical University School of Basic Medicine Professors and others have contributed to this work